Curriculum: Drug Sciences

Supervisor: Chiara Sinico

Co-Supervisor: Francesco Lai, Michele Schlich

Curriculum Vitae

Adeela Yasmin, is a doctoral Researcher in department of Life, Environmental and Drug Sciences, University of Cagliari. Her main areas of research centered around nanotechnology, optimization of nanocarriers for enhanced drug delivery prominently but not limited to liposomes, transferosomes and nanofibers and wounds healing. Previously she earned master’s degree in Food science and nutraceuticals and served as lecturer at public university in Pakistan. Her main responsibilities include teaching and instructing courses regarding metabolism of nutrients, food therapeutics, extraction and characterization of bioactive compounds from natural sources and application in product development. She also holds experience of working in nutraceutical industries.

Research Topic

Electrospun nanofibers as topical delivery system for diabetic wound healing

Abstract

Yasmin Adeela's research project focuses on the development of nanofibers as topical delivery systems for wound healing. Diabetic wounds are complications in patients with diabetes that take a long time to resolve. These wounds produce high levels of inflammatory cytokines and reactive oxygen species, which further damages the normal tissues. Moreover, their hyperglycemic environments exhibit repeated bacterial infections which cause great suffering to the patients and result in significant burden on health care systems. Hence, formulation of wound dressings is crucial to protect and accelerate wound closure. Electrospun nanofibers are a promising option for diabetic wound closure because of their structural similarity to the extracellular matrix (ECM), which induces proliferation, cell adhesion and migration, hence leading to new tissue formation. Compared to conventional wound dressing materials, electrospun nanofiber based wound patches have high porosity and moisture permeability, and they provide an effective barrier against pathogen invasion. They can encapsulate and deliver active substances that promote wound healing. Co-loading of nanofibers with multiple bioactive agents might lead to synergistic action in diabetic wound healing. The current research is aimed to fabricate nanofibers using plant-derived natural bioactive compounds. For this purpose, we are focusing on natural compounds able to target different phases of wound healing. Hence their inclusion into nanofibers would allow their controlled release at target wound site and will eventually help in the management and treatment of hard-to-heal diabetic wounds.

Publications

IRIS: https://iris.unica.it/cris/rp/rp87696

ORCID: https://orcid.org/0009-0009-3965-5243