Università degli Studi di Cagliari
Ciclo di seminari del prof. Marco A. Ciufolini, University of British Columbia (Vancouver, Canada)
08 marzo 2012
Ciclo di seminari con il prof. Marco A. Ciufolini, della University of British Columbia (Vancouver, Canada), organizzati dal Dipartimento di Scienze della vita e dell’ambiente - Sezione di Scienze del farmaco - a partire da giovedì 8 marzo 2012. Tutti gli appuntamenti si svolgeranno nell’ Aula 2 del Palazzo delle Scienze, con inizio alle ore 16. Richiesto il rilascio di 1 CFU per gli studenti partecipanti.
giovedì 8 marzo
A. A pyridone-forming reaction: camptothecin and the development of Karenithecin
Significance of topoisomerase I and camptothecin (CPT) in oncology
Problems associated with medicinal chemistry studies on CPT
Development of a pyridine-forming reaction and total synthesis of CPT
Highly lipophilic CPT analogs: Karenithecin
martedì 13 marzo
B. Liposomal drug formulations: taxanes, streptonigrinoids, siRNA.
Significance of tubulin and taxanes in oncology
Significance of siRNA in contemporary biomedicine
Problems associated with the delivery of highly water-insoluble drugs
Challenges inherent to the delivery of siRNA
Novel lipids enabling the liposomal formulation & delivery of the above
venerdì 16 marzo
C. New pyridine chemistry: thiopeptides and the development of Masitinib
The antibiotics crisis
Emerging interest in thiopeptide antibiotics
Current hypotheses regarding thiopeptide structure-activity relationship
Methodology for the synthesis of thiopeptides
Current research in the thiopeptide area
Biochemical significance of protein phosphokinases
From antibiotics to kinase inhibitors: the development of Masitinib
martedì 20 marzo
D. Oxidative amidation of phenols: FR901483 and Tetrodotoxin
Significance of immunosuppressant in modern medicine
Oxidative amidation of phenols and the synthesis of FR901483
Modulating Na+ ion channel function: challenges and opportunities
Efforts toward tetrodotoxin and congeners
INFO
Dr Graziella Tocco, PhD, Assistant Professor
Dr Graziella Tocco, PhD, Assistant Professor
tel. +390706758551/8711 - Fax +390706758553