A novel series of 3,4-disubstituted dihydropyrazoles: Synthesis and evaluation for MAO enzyme inhibition

CARDIA, MARIA CRISTINA;SANNA, MARIA LUISA;MELEDDU, RITA;DISTINTO, SIMONA;Yañez M.;Viña D.;Lamela M.;MACCIONI, ELIAS

2013-01-01

---

Abstract

In this study, the authors have designed and synthesized a novel series of 3-acyl-4-aryl-4,5-dihydropyrazoles, with the aim to obtain new potential scaffolds for the inhibition of both isoforms of monoamine oxidase (MAO) enzyme. The synthetic pathway to these compounds includes as a key step the 1,3-dipolar cycloaddition reaction of diazomethane with a chalcone. All the compounds were fully characterized by means of spectroscopic and analytical data and showed speci fi c inhibition against MAO A.