A novel series of 3,4-disubstituted dihydropyrazoles: Synthesis and evaluation for MAO enzyme inhibition

CARDIA, MARIA CRISTINA;SANNA, MARIA LUISA;MELEDDU, RITA;DISTINTO, SIMONA;MACCIONI, ELIAS
2013-01-01

Abstract

In this study, the authors have designed and synthesized a novel series of 3-acyl-4-aryl-4,5-dihydropyrazoles, with the aim to obtain new potential scaffolds for the inhibition of both isoforms of monoamine oxidase (MAO) enzyme. The synthetic pathway to these compounds includes as a key step the 1,3-dipolar cycloaddition reaction of diazomethane with a chalcone. All the compounds were fully characterized by means of spectroscopic and analytical data and showed speci fi c inhibition against MAO A.
2013
Inglese
JOURNAL OF HETEROCYCLIC CHEMISTRY
50
SUPPL.1
E87
E92
6
WOS:000318428200013
2-s2.0-84876943521
Esperti anonimi
internazionale
scientifica
sì
Cardia, MARIA CRISTINA; Sanna, MARIA LUISA; Meleddu, Rita; Distinto, Simona; Yañez, M.; Viña, D.; Lamela, M.; Maccioni, Elias
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
8
reserved
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