Synthesis and biological evaluation of new 3-phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones

Bielenica A;Kossakowski J;Struga M;Dybala I;LODDO, ROBERTA;IBBA, CRISTINA;La Colla P.

2011-01-01

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Abstract

A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.