Synthesis and biological evaluation of new 3-phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones

LODDO, ROBERTA;IBBA, CRISTINA;
2011-01-01

Abstract

A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
2011
Inglese
SCIENTIA PHARMACEUTICA
79
2
225
238
14
2-s2.0-79959285202
21773062
http://dx.doi.org/10.3797/scipharm.1012-17
Esperti anonimi
internazionale
scientifica
3-Phenylpiperidine-2,6-dione; Antiviral activity; Cytotoxicity; X-ray crystallography
sì
Bielenica, A; Kossakowski, J; Struga, M; Dybala, I; Loddo, Roberta; Ibba, Cristina; La Colla, P.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
7
open
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