Distribution of HLA alleles and haplotypes in the Maldivian population

Testi M;Lai S;ORRU, SANDRO

Supervision

;Alba F;Cappai L;Firdous N;Gaziev J;Troiano M;Andreani M;CARCASSI, CARLO

Ultimo

Writing – Review & Editing

2011-01-01

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Abstract

The study of human leukocyte antigen (HLA), allele and haplotype frequencies within populations provides an important source of information for anthropological investigation, organ and hematopoietic stem-cell transplantation purposes as well as disease association studies. As of today, there are no data available in the literature on the HLA structure of the Maldivian population. Altogether 106 families were studied. We used the parents of each family (212 unrelated individuals) to analyze the frequencies of HLA class I and class II allele groups and haplotypes.