Delta9-THC and heroin exposure in adolescence differently affect heroin self-administration in adulthood

LECCA, DANIELE;VALENTINI, VALENTINA;SCIFO, ANDREA;
2013-01-01
2013
-
Dopamine 2013
contributo
24-28/05/2013
Alghero, Sardinia, Italy
internazionale
Lewis (LEW) and Fischer (F344) inbred strains are differentially sensitive to the reinforcing properties of drugs of abuse. Using these strains we evaluated the influence of adolescent pre-exposure to Delta9-THC and heroin on heroin self-administration (SA) and reinstatement in adulthood. On the the 6th postnatal (PN) week rats were administered twice a day with increasing doses of heroin (Exp. I: 5,10,20 mg/kg, s.c.) and Delta9-THC (Exp. II: 2,4,8 mg/kg, i.p.) for three consecutive days. In adulthood (10th PN week), LEW and F344 rats were trained to acquire intravenous heroin SA (0.025 mg/kg dose unit) under fixed ratio (FR) schedules in Skinner boxes equipped with active and inactive nose-poking holes. In both experiments LEW rats showed higher operant responding activity and faster acquisition of opiate-reinforced behavior as compared to F344 rats. In LEW rats heroin pre-exposure in adolescence resulted in increased responding for heroin and increased heroin intake compared to controls rats as well as to F344 group on FR3 schedule (Exp.I). Adolescent pre-exposure of LEW rats to Delta9-THC resulted in a faster increase of responding when switching ratio schedule from FR-1 to FR-3 and FR-5 (Exp.II). During reinstatement LEW pretreated rats showed greater nose poking behavior compared to controls rats as well as to F344 group. These results demonstrate the importance of strain-related difference in the influence of adolescent heroin and Delta9-THC pre-exposure on heroin reinforcing properties in adulthood. Additional studies of heroin SA behavior under progressive ratio schedules in Delta9-THC pretreated LEW and F344 rats are still going on.
275
info:eu-repo/semantics/conferencePoster
4.3 Poster
6
4 Contributo in Atti di Convegno (Proceeding)::4.3 Poster
none
Lecca, Daniele; Cadoni, C; Valentini, Valentina; Piras, G; Scifo, Andrea; Di Chiara, G.
4.3 Poster
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