Protective effect of Hypericum hircinum on doxorubicin-induced cardiotoxicity in rats

Shah S;Mohan M;Kasture S;BALLERO, MAURO;MAXIA, ANDREA;SANNA, CINZIA

2013-01-01

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Abstract

Oxidative stress is the main factor in doxorubicin (DOX) induced cardiotoxicity. Wistar rats received either DOX (3mgkg(-1), i.p.) every other day or combination of Hypericum hircinum (100 and 200mgkg(-1), p.o.) and DOX or H. hircinum (200mgkg(-1), p.o.) extract alone for 2 weeks. Cardiotoxicity was assessed by recording changes in ECG, heart rate and measuring the levels of cardiac marker enzymes - lactic acid dehydrogenase, creatine phosphokinase, glutamic oxaloacetic transaminase, the antioxidant defence enzymes - reduced glutathione (GSH), superoxide dismutase (SOD) and lipid peroxidative value (LPO) at the end of treatment schedule. Treatment with H. hircinum significantly (p<0.05) decreased the levels of LPO and marker enzymes, increased the levels of GSH and SOD, reversed the changes in ECG and prevented the decrease in heart weight in DOX-treated group. The results suggest that H. hircinum has the potential to prevent the cardiotoxic effects induced by DOX.