Synthesis of cyclobutane-fused oxazolidine-2-thione derivatives

Barranco S.;Cuccu F.;Devoto F.;Guillot R.;Caboni P.;Aitken D. J.;Frongia A.

2024-01-01

---

Abstract

An expedient, solvent-free, mild base catalyzed intermolecular cyclization reaction has been developed to enable the one-pot synthesis of fourteen examples of cyclobutane-fused oxazolidine-2-thiones in good to high yields. Bicyclic structures of this type have not previously been described in the literature; they have a cis ring junction with both rings deviating slightly from planarity.