Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Lupia, Antonio;
2023-01-01

Abstract

The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including pancreatic ductal adenocarcinoma (PDAC). LIF signaling is mediate by its binding to the heterodimeric LIF receptor (LIFR) complex formed by the LIFR receptor and Gp130, leading to JAK1/STAT3 activation. Bile acids are steroid that modulates the expression/activity of membrane and nuclear receptors, including the Farnesoid-X-Receptor (FXR) and G Protein Bile Acid Activated Receptor (GPBAR1).
2023
Inglese
FRONTIERS IN ONCOLOGY
13
1
17
17
WOS:000956766300001
2-s2.0-85150864923
36998446
Esperti anonimi
scientifica
bile acids; EMT; LIF; LIFR; PDAC; proliferation; steroid
Goal 4: Quality education
no
Di Giorgio, Cristina; Bellini, Rachele; Lupia, Antonio; Massa, Carmen; Bordoni, Martina; Marchianò, Silvia; Rosselli, Rosalinda; Sepe, Valentina; Rapa ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
19
open
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