Adjuvant chemotherapy for resected triple negative breast cancer patients: A network meta-analysis

Petrelli, Fausto;Bertaglia, Valentina;Parati, Maria Chiara;Borgonovo, Karen;De Silva, Pushpamali;Luciani, Andrea;Novello, Silvia;Scartozzi, Mario;Emens, Leisha A;Solinas, Cinzia

2023-01-01

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Abstract

The current standard of care for resected early-stage triple negative breast cancer (TNBC) patients who did not receive systemic preoperative therapy is adjuvant anthracycline- and taxane-based chemotherapy (CT). A network meta-analysis (NMA) of randomized controlled trials (phase III) enrolling patients with resected stage I-III TNBC comparing adjuvant regimens was performed. Overall survival (OS) and disease-free survival (DFS) data were extracted. A total of 27 phase III clinical trials were selected including 15,242 TNBC patients. This NMA showed an OS benefit from the incorporation of capecitabine into classic anthracycline/taxane-based combinations compared to anthracyclines with or without taxanes alone.