Epigenetic mechanisms in oral cancer: new diagnostic and therapeutic strategies

SCANO A

Primo

Conceptualization

;CASU C

Secondo

Methodology

;ORRU G

Penultimo

Conceptualization

;CONI P.

Ultimo

2022-01-01

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Abstract

Complexity and heterogeneity are frequently present during the development and progression of carcinogenesis and, in the last 15 years, significant progress made in clinical research underlines the role of some epigenetic mechanisms. The most important characteristics of the epigenetic concept are that these events are reversible, not related to modifications in the structure of DNA and may drive fundamental cell signaling alterations1. Among these systems of communication in normal and pathological conditions, also microbiome and staminal cells2 seem to be important. These new profiles of pathological communication develop novel diagnostic, prognostic and therapeutic tools