N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

Basoccu, Francesco;Fattuoni, Claudia
;Porcheddu, Andrea
2022-01-01

Abstract

The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
2022
2022
Inglese
MOLECULES
27
17
5450
1
11
11
WOS:000851809900001
2-s2.0-85137779353
36080215
Esperti anonimi
internazionale
scientifica
formamides; green chemistry; ball milling; mechanochemistry; saccharin
no
Cuccu, Federico; Basoccu, Francesco; Fattuoni, Claudia; Porcheddu, Andrea
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
4
open
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