Decreased Frontal Gamma Activity in Alzheimer Disease Patients

Casula, Elias P;Pellicciari, Maria C;Bonnì, Sonia;Borghi, Ilaria;Maiella, Michele;Assogna, Martina;Minei, Marilena;Motta, Caterina;D'Acunto, Alessia;Porrazzini, Francesco;Pezzopane, Valentina;Mencarelli, Lucia;Roncaioli, Andrea;Rocchi, Lorenzo

Writing – Review & Editing

;Spampinato, Danny A;Caltagirone, Carlo;Santarnecchi, Emiliano;Martorana, Alessandro;Koch, Giacomo

2022-01-01

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Abstract

In Alzheimer disease (AD) animal models, synaptic dysfunction has recently been linked to a disorder of high-frequency neuronal activity. In patients, a clear relation between AD and oscillatory activity remains elusive. Here, we attempt to shed light on this relation by using a novel approach combining transcranial magnetic stimulation and electroencephalography (TMS-EEG) to probe oscillatory activity in specific hubs of the frontoparietal network in a sample of 60 mild-to-moderate AD patients.