Reactive-Oxygen-Species-Mediated Surface Oxidation of Single-Molecule DNA Origami by an Atomic Force Microscope Tip-Mounted C 60 Photocatalyst

Cristiana Passiu;Antonella Rossi;
2021-01-01

Abstract

Spatially controlled single-molecule oxidation of DNA was performed by photocatalytic generation of singlet oxygen on chemically functionalized AFM tips. A waffle-type DNA origami deposited on a mica surface is site-specifically destroyed by generation of reactive oxygen species at the AFM tip, which was modified with C60-tripod photocatalyst. Upon AFM scanning under photoirradiation, DNA morphology changes, corresponding to oxidative damage were clearly observed at the single-molecule level. The DNA cleavage occurred with strict dependence on photoirradiation and the presence of C60 on the AFM tip.
2021
2021
Inglese
ACS NANO
WOS:000751890100044
2-s2.0-85120578345
https://pubs.acs.org/doi/10.1021/acsnano.1c04953
Esperti anonimi
internazionale
scientifica
atomic force microscope, reactive oxygen species, singlet oxygen, DNA origami, C60 photocatalyst, single molecule
sì
Ray, Ankita; Passiu, Cristiana; Nasuda, Masayuki; Ramakrishna, Shivaprakash N.; Rossi, Antonella; Kuzuya, Akinori; Spencer, Nicholas D.; Yoko Yamakosh ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
8
none
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