Evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins functionally interact with human and drosophila tar DNA-binding protein 43 (TDP-43)

Feiguin, F.
2014-01-01

Abstract

Background: TDP-43 and hnRNPA1/A2 factors are implicated in neurodegeneration. Results: The human and fruit fly TDP-43 and hnRNPA1/A2 orthologs show physical, genetic, and functional interplays. Conclusion: The functional cooperation between TBPH/Hrp38 and TDP-43/hnRNP A/B is conserved throughout evolution. Significance: TBPH/Hrp38 interplay can be critical for neurodegeneration, and Drosophila is a model suitable to study the impact of this interaction. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
2014
Inglese
289
10
7121
7130
10
WOS:000332389400071
2-s2.0-84896771214
Esperti anonimi
internazionale
scientifica
Drosophila; Neuroscience; Retinal Degeneration; RNA Splicing; RNA-binding Proteins; Hrb98DE; Hrp38; hnRNP A; TDP-43; TBPH; B
sì
Romano, M.; Buratti, E.; Romano, G.; Klima, R.; Del Bel Belluz, L.; Stuani, C.; Baralle, F.; Feiguin, F.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
8
open
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