Antioxidant approach as a cardioprotective strategy in chemotherapy-induced cardiotoxicity

Cadeddu Dessalvi, Christian

Primo

;Deidda, Martino;Noto, Antonio;Madeddu, Clelia;Cugusi, Lucia;Santoro, Ciro;López-Fernández, Teresa;Galderisi, Maurizio;Mercuro, Giuseppe

2021-01-01

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Abstract

Recent Advances: An antioxidant approach as a cardioprotective strategy in this setting has shown encouraging results in preventing anticancer drug-induced CTX.Critical Issues: In fact, traditional heart failure drugs as well as many other compounds and nonpharmacological strategies, with a partial effect in reducing oxidative stress, have been shown to counterbalance chemotherapy-induced CTX in this setting to some extent.Future Directions: Given the various pathways of toxicity involved in different chemotherapeutic schemes, interactions with redox balance need to be fine-tuned and a personalized cardioprotective approach seems to be required.