Efficacy and safety of the 5-Hydroxytryptophan on Depression and Apathy in Parkinson's disease: a preliminary finding

Meloni, Mario;Puligheddu, Monica;Carta, Manolo;Cannas, Antonino;Figorilli, Michela;Defazio, Giovanni

Ultimo

2020-01-01

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Abstract

Several studies have indicated that altered serotonergic neurotransmission may contribute to non-motor features commonly associated with Parkinson's disease (PD) such as apathy and depression.The 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of L-tryptophan in the production of serotonin. To date, there has been inconsistent research on the use of 5-HTP in PD. The purpose of this study was to compare the effects of 5-HTP to placebo on apathy and depressive symptoms in patients with PD.