Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies

Krohn, Lynne;Wu, Richard Y J;Heilbron, Karl;Ruskey, Jennifer A;Laurent, Sandra B;Blauwendraat, Cornelis;Alam, Armaghan;Arnulf, Isabelle;Hu, Michele T M;Dauvilliers, Yves;Högl, Birgit;Toft, Mathias;Bjørnarå, Kari Anne;Stefani, Ambra;Holzknecht, Evi;Monaca, Christelle Charley;Abril, Beatriz;Plazzi, Giuseppe;Antelmi, Elena;Ferini-Strambi, Luigi;Young, Peter;Heidbreder, Anna;Cochen De Cock, Valérie;Mollenhauer, Brit;Sixel-Döring, Friederike;Trenkwalder, Claudia;Sonka, Karel;Kemlink, David;Figorilli, Michela;Puligheddu, Monica;Dijkstra, Femke;Viaene, Mineke;Oertel, Wolfang;Toffoli, Marco;Gigli, Gian Luigi;Valente, Mariarosaria;Gagnon, Jean-François;Nalls, Mike A;Singleton, Andrew B;Desautels, Alex;Montplaisir, Jacques Y;Cannon, Paul;Ross, Owen A;Boeve, Bradley F;Dupré, Nicolas;Fon, Edward A;Postuma, Ronald B;Pihlstrøm, Lasse;Rouleau, Guy A;Gan-Or, Ziv

2020-01-01

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Abstract

Rapid eye movement sleep behavior disorder (RBD) is a prodromal synucleinopathy, as >80% will eventually convert to overt synucleinopathy. We performed an in-depth analysis of the SNCA locus to identify RBD-specific risk variants.