Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Riva I;Legramandi L;Rulli E;Konstas AG;Katsanos A;Oddone F;Weinreb RN;Quaranta L;Varano L;Carchedi T;Talarico S;Parravano F;Motolese I;Bagaglia SA;Rossi GCM;Lateri S;Bossolesi L;Carmassi L;Rolle T;Piccini R;Ratiglia R;Rossi A;Gandolfi S;Tagliavini;Ungaro N;Fossarello M;Cuccu A;Zucca I;Uva M;Bonacci E;Cardarella G;Tognetto D;Vattovani O;Vallon P;Iannacone F;Fontana L;Marchi S;Manni GL;Jannetta D;Roberti G;Rossetti L;Maggiolo E;Oneta O;Sborgia C;Cantatore F;Mastropasqua L;Agnifili L;Campos E;Gizzi C;Giannaccare G;Pucci;Cassamali M;Costagliola C;Traverso C;Scotto R;Musolino M;Landi L;Bagnis A.

2019-01-01

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Abstract

To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.