The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective

Manolo Carta;
2018-01-01

Abstract

During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson's disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.
2018
2018
Inglese
125
8
1195
1202
8
Esperti anonimi
internazionale
scientifica
Parkinson’s disease; dyskinesia; serotonin; serotonin autoreceptors; L-DOPA
Carta, Manolo; Björklund, Anders
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
2
reserved
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