FUSOBACTERIUM NUCLEATUM IN CHILDREN’S ORAL CAVITY. A COMMENSAL TURNED PATHOGEN THAT INCREASED RADICALLY IN 5,000 YEARS.

Maria Paola Contu

Primo

Methodology

;Eleonora Casula

Methodology

;Ornella Fonzo

Validation

;Giacomo Paglietti

Validation

;Elena Usai

Conceptualization

;Gloria Denotti

Methodology

;Valentino Garau

Conceptualization

;Rossana Martorelli

Investigation

;Ferdinando Coghe

Data Curation

;Germano Orrù

Ultimo

Writing – Review & Editing

2018-01-01

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Abstract

The Gram-negative bacterium Fusobacterium nucleatum (Fn), is part of normal placental and oral microbiome, in particular tongue and dental plaque. In the same way, it is strictly associated with a set of diseases that increased in recent years: preterm birth, colorectal cancer, inflammatory bowel disease, periodontitis [1]. In the oral cavity, Fn concentration/growth results strictly related to human habits, such as alimentation and smoke. This research aims to determine the rate of this pathogen in oral biological samples (dental calculi) from 5,000 years ago to nowadays.