Mechanochemistry for "no solvent, no base" preparation of hydantoin-based active pharmaceutical ingredients: Nitrofurantoin and dantrolene
Colacino, E.
Primo
;Porcheddu, A.
Secondo
;Delogu, F.Funding Acquisition
;
2018-01-01
Abstract
The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin©), dantrolene (Dantrium©) and their structurally related derivatives is herein reported. Not a drop of organic solvent was used for the entire process and high yields of pure compounds were obtained without post-reaction work-up. Hydrazones were stable in the presence of water and gaseous HCl, formed as by-products during the synthesis. Comparative mechanochemical experiments were performed using diverse milling devices and jar materials, the active pharmaceutical ingredients were analyzed by PXRD and green metrics are calculated.File | Dimensione | Formato | |
---|---|---|---|
Green Chemistry.pdf Solo gestori archivio
Tipologia: versione editoriale
Dimensione 344.59 kB
Formato Adobe PDF
|
344.59 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.