Synthesis and binding of 3-aminopyridine derivatives at central nicotinic receptors

BALBONI, GIANFRANCO;
2000-01-01

Abstract

A series of secondary and tertiary pyridyl amides as potential central nicotinic acetylcholine receptors (nAChRs) ligands were prepared. Amides displayed negligible or very low affinity, whereas two amines achieved by reduction of corresponding secondary amides, showed affinity in the nanomolar range for nAChRs
2000
Inglese
ARZNEIMITTEL-FORSCHUNG
50
507
511
5
WOS:000087965100001
2-s2.0-0033946023
Esperti anonimi
3-aminopyridine derivatives; receptor binding; synthesis; nicotinic receptors ligands; central
I synthesized the compounds.
Balboni, Gianfranco; Marastoni, M.; Merighi, S.; Borea, P. A.; Tomatis, R.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
5
none
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