Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice

RUOCCO LA;VIGGIANO D;PIGNATELLI M;IANNACCONE T;RIMOLI MG;MELISI D;CURCIO A;DE LUCIA S;CARBONI, EZIO;CARNEVALE UA;DE CAPRARIIS P;SADILE AG

2008-01-01

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Abstract

11. Behav Brain Res. 2008 Mar 5;187(2):449-54. Epub 2007 Oct 13. Galactosilated dopamine increases attention without reducing activity in C57BL/6 mice. Ruocco LA, Viggiano D, Pignatelli M, Iannaccone T, Rimoli MG, Melisi D, Curcio A, De Lucia S, Carboni E, Gironi Carnevale UA, de Caprariis P, Sadile AG. Department of Experimental Medicine, II University of Naples, Italy. Different strategies can be used to carry dopamine into the brain such as L-Dopa precursors or galactosilated form of DA (GAL-DA). The aim of this study was to investigate whether GAL-DA would reduce hyperactivity and increase non-selective attention (NSA) in a mouse model of attention deficit hyperactivity disorder (ADHD), as, i.e. C57BL/6 as did in NHE rats. Here we report that GAL-DA increases NSA in a spatial novelty in C57BL/6 mice. They received a single i.p. injection of GAL-DA (10 mg/kg or 100 mg/kg) or equimolar galactose vehicle. Another mouse strain the Swiss albino was introduced as inbred control group. Three hours after last injection mice were tested in a Làt-maze for 30-min. Behaviour was analyzed for horizontal (traveled distance) and vertical activity (orienting frequency and scanning durations) which shares cognitive and non-cognitive nature, respectively. Ten milligram per kilograms of GAL-DA, increases scanning duration in C57BL/6 mice. Thus a low dose of GAL-DA increases NSA without reducing hyperactivity in this mouse model of ADHD. PMID: 18063140 [PubMed - indexed for MEDLINE]