Esther Smith
The presence of a local immune system in the upper blind and lower part of the human nasolacrimal duct
PUXEDDU, ROBERTO;ZUCCA, IGNAZIO ALBERTO;PIRAS, FRANCA;PERRA, MARIA TERESA;MAXIA, CRISTINA
2000-01-01
Abstract
The nasolacrimal duct is exposed to exogenous agents, including potentially harmful microorganisms, coming from the eye surface by the lacrimal sac, and from the nasal cavity by the inferior meatus of the nose. The upper blind and lower part of the human nasolacrimal duct were examined immunohistochemically to ascertain the presence and localization of immunoglobulin-producing cells and the epithelial expression of IgA, IgM, and IgG in order to verify the possible antimicrobial properties of this duct. IgA-, IgM-, and IgG-positive immunocompetent cells were recognizable in the lamina propria of the upper blind and lower part of the human nasolacrimal duct, while an evident immunoreactivity for sIgA, IgM, and IgG was demonstrated in the cytoplasm of the apical epithelial cells. The results suggest that all the effector components of the mucosal immune system are present in that area of the human nasal mucosa next to the opening of the nasolacrimal duct as well as in the human lacrimal sac.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.