Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia
RONGIOLETTI, FRANCO;ATZORI, LAURA;FERRELI, CATERINA
2016-01-01
Abstract
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndromes are rare paraneoplastic conditions due to an underlying plasma cell dyscrasia. We report a 70-year-old patient with the rare coexistence of POEMS and AESOP syndromes and in whom skin signs, that differ both clinically and histologically, were the clues to the diagnosis of a plasma cell disorder. Vascular endothelial growth factor-A overexpression seems to be the common pathogenetic link of the different clinicopathological presentations of the skin lesions.File | Dimensione | Formato | |
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