Current views on anthracycline cardiotoxicity

Mele, Donato;Nardozza, Marianna;Spallarossa, Paolo;Frassoldati, Antonio;Tocchetti, Carlo G.;CADEDDU DESSALVI, CHRISTIAN;Madonna, Rosalinda;Malagù, Michele;Ferrari, Roberto;MERCURO, GIUSEPPE

2016-01-01

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Abstract

Anthracyclines are well established and effective anticancer agents used to treat a variety of adult and pediatric cancers. Unfortunately, these drugs are also among the commonest chemotherapeutic agents that have been recognized to cause cardiotoxicity. In the last years, several experimental and clinical investigations provided new information and perspectives on anthracycline-related cardiotoxicity. In particular, molecular mechanisms of cardiotoxicity have been better elucidated, early diagnosis has improved through the use of advanced noninvasive cardiac imaging techniques, and emerging data indicate a genetic predisposition to develop anthracycline-related cardiotoxicity. In this article, we review established and new knowledge about anthracycline cardiotoxicity, with special focus on recent advances in cardiotoxicity diagnosis and genetic profiling.