Study of a series of 8-substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE inhibitors

Matos, Maria João;Borges, Fernanda;Santana, Lourdes;Uriarte, Eugenio;MEDDA, ROSARIA;Murgia, Adriana;DI PETRILLO, AMALIA;ERA, BENEDETTA;FAIS, ANTONELLA;PINTUS, FRANCESCA

2015-01-01

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Abstract

In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases.