Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis

CAMPAGNA, MARCELLO;LOCCI, EMANUELA;PIRAS, ROBERTO;NOTO, ANTONIO;LECCA, LUIGI ISAIA;PILIA, ILARIA;COCCO, PIER LUIGI;D'ALOJA, ERNESTO;SCANO, PAOLA

2016-01-01

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Abstract

Objectives: 1H NMR-metabolomic approach was used to investigate QTc interval correlation with plasma metabolic profiles in shiftworkers. Methods: Socio-demographic data, electrocardiographic QTc interval and plasma metabolic profiles from 32 male shiftworkers, were correlated by multivariate regression analysis. Results: We found a positive correlation between QTc interval values, body mass index, glycemia and lactate level and a negative correlation between QTc interval and both pyroglutamate and 3-hydroxybutyrate plasma level. Conclusions: Our analysis provides evidence of the association between clinical, metabolic profiles and QTc interval values. This could be used to identify markers of early effects and/or susceptibility in shiftworkers