Synthesis of some novel 2,6-disubstituted pyridazin-3-ones as TMC120 analogues

LODDO, ROBERTA
2007-01-01

Abstract

Different analogues of TMC120 derived from pyridazin-3(2H)-one rings were synthesized by coupling of 3,6-dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives.
2007
Inglese
JOURNAL OF HETEROCYCLIC CHEMISTRY
44
6
1351
1356
6
WOS:000250794200018
Esperti anonimi
acetonitrile derivative; aniline derivative; benzyl bromide; pyridazine derivative; drug synthesis
Loksha, Ym; Pedersen, Eb; LA COLLA, P; Loddo, Roberta
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
4
none
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