Killer immunoglobulin-like receptors can predict TKI treatment-free remission in chronic myeloid leukemia patients

CAOCCI, GIOVANNI;GRECO, MARIANNA;RAGATZU, PAOLA;Mulas, Olga;CARCASSI, CARLO;LA NASA, GIORGIO
2015-01-01

Abstract

Several factors are predictive of treatment-free remission (TFR) in chronic myeloid leukemia (CML), but few data exist on the role of natural killer (NK) cells and their killer-cell immunoglobulin-like receptors (KIRs). KIR and human leukocyte antigen (HLA) genotypes were investigated in 36 CML patients who discontinued tyrosine kinase inhibitor (TKI) treatment after achieving deep molecular response (MR4.5). Cumulative TFR was significantly higher in patients homozygous for KIR A haplotype (85.7% vs. 45.5%; p = 0.029). Younger age, Bx haplotype, and the combination KIR3DS1/KIR3DL1 present/HLA-Bw4 present were significantly associated with relapse. KIR genotypes could prove useful in identifying patients that are likely to maintain MR4.5 after discontinuing TKI treatment.
2015
Inglese
43
12
1015
1018
4
www.elsevier.com/locate/exphem
Esperti anonimi
internazionale
scientifica
Cancer research; Cell biology; Genetics; Molecular biology; Hematology
no
Caocci, Giovanni; Martino, Bruno; Greco, Marianna; Abruzzese, Elisabetta; Trawinska, Malgorzata Monika; Lai, Sara; Ragatzu, Paola; Galimberti, Sara; B ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
15
reserved
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