Synthesis and antimicrobial activity of novel arylidenisothiosemicarbazones

CARDIA, MARIA CRISTINA;BEGALA, MICHELA;DE LOGU, ALESSANDRO;MACCIONI, ELIAS;PLUMITALLO, ANTONIO

2000-01-01

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Abstract

Arylidenimidazoles bearing a thioethereal function in the position 2 of the imidazole ring show good antimicrobial activity. We now report on the synthesis and the biological properties of some novel arylidenisothiosemicarbazones, structurally related to the arylideneiminoimidazoles of which they can be considered the linear precursors. Particular attention has been put on the influence of structural modifications on the biological activity.