Drug loaded fluorescent cubosomes:versatile nanoparticles for potential theranostic applications

MURGIA, SERGIO;Bonacchi S;FALCHI, ANGELA MARIA;LAMPIS, SANDRINA;LIPPOLIS, VITO;MELI, VALERIA;MONDUZZI, MAURA;Prodi L;Schmidt J;Talmon Y;CALTAGIRONE, CLAUDIA

2013-01-01

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Abstract

In this work, monoolein-based cubosomes were doped with two fluorescent probes, namely, fluorescein and dansyl, properly modified with a hydrocarbon chain to increase their encapsulation efficiency within the monoolein palisade. The same nanocarriers were also loaded with quercetin, a hydrophobic molecule with potential anticancer activity. Particularly, the cubosomes doped with the modified fluorescein probe were successfully exploited for single living cell imaging. The physicochemical and photophysical characterizations reported here, along with the well-known ability of cubosomes in hosting molecules with pharmaceutical interest, strongly encourage the use of these innovative fluorescent nanocarriers for theranostic purposes.