New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: synthesis and antitumoral activity

COCCO MT;CONGIU, CENZO;ONNIS, VALENTINA

2003-01-01

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Abstract

Bis(pyridyl)methane derivatives 5–40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5–40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10−5 M level and in some case at 10−7 M concentrations.