Gabriella Simbula
Glutamine Starvation Affects Cell Cycle, Oxidative Homeostasis and Metabolism in Colorectal Cancer Cells
2023-01-01 Spada, Martina; Piras, Cristina; Diana, Giulia; Leoni, Vera Piera; Frau, Daniela Virginia; Serreli, Gabriele; Simbula, Gabriella; Loi, Roberto; Noto, Antonio; Murgia, Federica; Caria, Paola; Atzori, Luigi
The impact of the secondary infections in ICU patients affected by COVID-19 during three different phases of the SARS-CoV-2 pandemic
2023-01-01 Murgia, Federica; Fiamma, Maura; Serra, Silvia; Marras, Giulia; Argiolas, Raul; Mattana, Chiara; Mattu, Maria Grazia; Garau, Maria Cristina; Doneddu, Sonia; Olla, Sabrina; Cocco, Eleonora; Lorefice, Lorena; Muntoni, Sandro; Paffi, Peppino; Porru, Stefano; Abis, Marta; Bellizzi, Saverio; Pani, Antonello; Angioi, Andrea; Simbula, Gabriella; Mussap, Michele; Massidda, Orietta; Carta, Franco; Atzori, Luigi
Role of the Hippo pathway in liver regeneration and repair: recent advances
2022-01-01 Pibiri, Monica; Simbula, Gabriella
α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells
2020-01-01 Pibiri, Monica; Sulas, Pia; Camboni, Tania; Leoni, VERA PIERA; Simbula, Gabriella
Boosting phagocytosis and anti-inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease
2018-01-01 Lecca, Daniela; Janda, Elzbieta; Mulas, Giovanna; Diana, Andrea; Martino, Concetta; Angius, Fabrizio; Spolitu, Stefano; Antonietta Casu, M; Simbula, Gabriella; Boi, Laura; Batetta, Barbara; Spiga, Saturnino; Carta, Annarosa
A novel lactoferrin-modified stealth liposome for hepatoma-delivery of triiodothyronine
2018-01-01 Pireddu, R; Pibiri, M; Valenti, D; Sinico, C; Fadda, Am; Simbula, G; Lai, F.
Solvent-Free addition of indole to aldehydes: Unexpected synthesis of novel 1-[1-(1h-indol-3-yl) alkyl]-1h-indoles and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells
2017-01-01 Tocco, Graziella; Zedda, Gloria; Casu, Mariano; Simbula, Gabriella; Begala, Michela
Differential induction of dyskinesia and neuroinflammation by pulsatile versus continuous L-DOPA delivery in the 6-OHDA model of Parkinson's disease
2016-01-01 Mulas, Giovanna; Espa, Elena; Fenu, Sandro; Spiga, Saturnino; Cossu, Giovanni; Pillai, Elisabetta; Carboni, Ezio; Simbula, Gabriella; Jadzic, Dragana; Angius, Fabrizio; Spolitu, Stefano; Batetta, Barbara; Lecca, Daniela; Giuffrida, Andrea; Carta, Annarosa
Cytotoxicity evaluation of a new resin-based hybrid root canal sealer: an in vitro study
2014-01-01 Cotti, Elisabetta; Petreucic, V; Re, D; Simbula, Gabriella
Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease
2014-01-01 Pisanu, Augusta; Lecca, Daniela; Mulas, Giovanna; Wardas, Jadwiga; Simbula, Gabriella; Spiga, Saturnino; Carta, Annarosa
Mild Synthetic Approach to Novel Indole-1-Carbinols and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells
2012-01-01 Zedda, G; Simbula, G; Begala, M; Pibiri, M; Floris, C; Casu, M; Casu, L; Tocco, G
NOVEL 1-[1-(1H-INDOL-3-YL)ALKYL]-1H-INDOLES AND INDOLE-1-CARBINOLS: SYNTHESIS AND EVALUATION OF CYTOTOXICITY IN HEPATOCARCINOMA CELLS.
2010-01-01 Tocco, Graziella; Zedda, G; Simbula, Gabriella; Pibiri, G; Casu, Mariano; Floris, Costantino; Podda, G; Begala, Michela
Comparison of tetraacetylethylendiamine + sodium perborate and sodium hypochlorite cytotoxicity on L929 fibroblasts
2010-01-01 Simbula, Gabriella; Dettori, Claudia; Camboni, Tania; Cotti, Elisabetta
Alpha-lipoic acid promotes the growth of rat hepatic preneoplastic lesions in the choline deficient model
2008-01-01 Perra, Andrea; Pibiri, Monica; Sulas, P; Simbula, Gabriella; Ledda, GIOVANNA MARIA; Columbano, Amedeo
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats
2008-01-01 Perra, Andrea; Simbula, Gabriella; Simbula, M; Pibiri, Monica; Kowalik, MARTA ANNA; Sulas, P; Cocco, Mt; Ledda, GIOVANNA MARIA; Columbano, Amedeo
ALFA-LIPOIC ACID ENHANCES CHOLINE DEFICIENT DIET-INDUCED FATTY LIVER AND STEATOHEPATITIS, AND PROMOTES THE GROWTH OF PRENEOPLASTIC LESIONS IN RAT LIVER. POSTER EASL
2007-01-01 Perra, Andrea; Simbula, Gabriella; Pibiri, Monica; Sulas, P; LEDDA COLUMBANO G., M; Columbano, A.
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
2007-01-01 Simbula, Gabriella; Columbano, Amedeo; Ledda, GIOVANNA MARIA; Sanna, L; Deidda, M; Diana, Andrea; Pibiri, Monica
The peroxisome proliferator BR931 kills FaO cells by p53-dependent apotosis
2004-01-01 Simbula, Gabriella; Pibiri, Monica; L., Sanna; C., Cossu; F., Molotzu; Columbano, Amedeo; Ledda, GIOVANNA MARIA
Induction of hepatocyte proliferation by retinoic acid
2004-01-01 Ledda, GIOVANNA MARIA; Pibiri, Monica; Molotzu, F; Cossu, C; Sanna, L; Simbula, Gabriella; Perra, Andrea; Columbano, Amedeo
Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand TCPOBOP
2003-01-01 Ledda, GIOVANNA MARIA; Pibiri, Monica; Concas, D.; Molotzu, F.; Simbula, Gabriella; Cossu, C.; Columbano, Amedeo
Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes
2001-01-01 Ishigami, T; Fujita, T; Simbula, Gabriella; Columbano, Amedeo; Kikuchi, K; Ishigami, A; Shimosawa, T; Arakawa, Y; Maruyama, N.
Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3)
2001-01-01 Pibiri, Monica; Ledda, GIOVANNA MARIA; Cossu, C; Simbula, Gabriella; Menegazzi, M; Shinozuka, H; Columbano, Amedeo
Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition in cultured hepatocytes
1997-01-01 Simbula, Gabriella; P. A., GLASCOTT JR; S., Akita; J. B., Hoek; J. L., Farber
The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition
1996-01-01 J. G., Pastorino; Simbula, Gabriella; K., Yamamoto; P. A., GASCOTT JR; R. J., Rothman; J. L., Farber
Dexametasone inhibits induction of liver Tumor Necrosis Factor-a mRNA and liver growth induced by lead nitrate and ethylene dibromide
1994-01-01 Ledda, GIOVANNA MARIA; Columbano, Amedeo; A., Cannas; Simbula, Gabriella; K., Okita; K., Kayano; Y., Kubo; S. L., Katyal; H., Shinozuka
Protoporphirine IX, an endogenous ligand of th peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone
1994-01-01 J. G., Pastorino; Simbula, Gabriella; E., Gilfor; J. B., Hoek; J. L., Farber
Proliferazione cellulare ed epatocarcinogenesi chimica
1994-01-01 Simbula, Gabriella; A., Cannas; A., Columbano
DEXAMETHASONE INHIBITS INDUCTION OF LIVER-TUMOR NECROSIS FACTOR-ALPHA MESSENGER-RNA AND LIVER GROWTH INDUCED BY LEAD NITRATE AND ETHYLENE DIBROMIDE
1994-01-01 Ledda, GIOVANNA MARIA; Columbano, Amedeo; Cannas, A; Simbula, Gabriella; Okita, K; Kayano, K; Kubo, Y; Katyal, Sl; Shinozuka, H.
Compensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis
1993-01-01 Ledda, GIOVANNA MARIA; Coni, Pierpaolo; Simbula, Gabriella; Zedda, I; Columbano, Amedeo
Differences in the steady-state levels of c-fos, c-jun and c-myc messanger RNA during mitogen-induced liver growth and compensatory regeneration
1993-01-01 Coni, Pierpaolo; Simbula, Gabriella; DE PRATI, Ac; Menegazzi, M; Suzuki, H; Sarma, Ds; Ledda, GIOVANNA MARIA; Columbano, Amedeo
Different effects of regenerative and direct mitogenic stimuli on the growth of initiated cells in the resistant hepatocyte model
1993-01-01 Coni, Pierpaolo; PICHIRI CONI, G; Curto, M; Simbula, Gabriella; Giacomini, L; Sarma, Ds; Ledda, GIOVANNA MARIA; Columbano, Amedeo
Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
---|---|---|---|---|
Glutamine Starvation Affects Cell Cycle, Oxidative Homeostasis and Metabolism in Colorectal Cancer Cells | 1-gen-2023 | Spada, Martina; Piras, Cristina; Diana, Giulia; Leoni, Vera Piera; Frau, Daniela Virginia; Serreli, Gabriele; Simbula, Gabriella; Loi, Roberto; Noto, Antonio; Murgia, Federica; Caria, Paola; Atzori, Luigi | ANTIOXIDANTS | - |
The impact of the secondary infections in ICU patients affected by COVID-19 during three different phases of the SARS-CoV-2 pandemic | 1-gen-2023 | Murgia, Federica; Fiamma, Maura; Serra, Silvia; Marras, Giulia; Argiolas, Raul; Mattana, Chiara; Mattu, Maria Grazia; Garau, Maria Cristina; Doneddu, Sonia; Olla, Sabrina; Cocco, Eleonora; Lorefice, Lorena; Muntoni, Sandro; Paffi, Peppino; Porru, Stefano; Abis, Marta; Bellizzi, Saverio; Pani, Antonello; Angioi, Andrea; Simbula, Gabriella; Mussap, Michele; Massidda, Orietta; Carta, Franco; Atzori, Luigi | CLINICAL AND EXPERIMENTAL MEDICINE | - |
Role of the Hippo pathway in liver regeneration and repair: recent advances | 1-gen-2022 | Pibiri, Monica; Simbula, Gabriella | INFLAMMATION AND REGENERATION | - |
α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells | 1-gen-2020 | Pibiri, Monica; Sulas, Pia; Camboni, Tania; Leoni, VERA PIERA; Simbula, Gabriella | SCIENTIFIC REPORTS | - |
Boosting phagocytosis and anti-inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease | 1-gen-2018 | Lecca, Daniela; Janda, Elzbieta; Mulas, Giovanna; Diana, Andrea; Martino, Concetta; Angius, Fabrizio; Spolitu, Stefano; Antonietta Casu, M; Simbula, Gabriella; Boi, Laura; Batetta, Barbara; Spiga, Saturnino; Carta, Annarosa | BRITISH JOURNAL OF PHARMACOLOGY | - |
A novel lactoferrin-modified stealth liposome for hepatoma-delivery of triiodothyronine | 1-gen-2018 | Pireddu, R; Pibiri, M; Valenti, D; Sinico, C; Fadda, Am; Simbula, G; Lai, F. | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
Solvent-Free addition of indole to aldehydes: Unexpected synthesis of novel 1-[1-(1h-indol-3-yl) alkyl]-1h-indoles and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells | 1-gen-2017 | Tocco, Graziella; Zedda, Gloria; Casu, Mariano; Simbula, Gabriella; Begala, Michela | MOLECULES | - |
Differential induction of dyskinesia and neuroinflammation by pulsatile versus continuous L-DOPA delivery in the 6-OHDA model of Parkinson's disease | 1-gen-2016 | Mulas, Giovanna; Espa, Elena; Fenu, Sandro; Spiga, Saturnino; Cossu, Giovanni; Pillai, Elisabetta; Carboni, Ezio; Simbula, Gabriella; Jadzic, Dragana; Angius, Fabrizio; Spolitu, Stefano; Batetta, Barbara; Lecca, Daniela; Giuffrida, Andrea; Carta, Annarosa | EXPERIMENTAL NEUROLOGY | - |
Cytotoxicity evaluation of a new resin-based hybrid root canal sealer: an in vitro study | 1-gen-2014 | Cotti, Elisabetta; Petreucic, V; Re, D; Simbula, Gabriella | JOURNAL OF ENDODONTICS | - |
Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease | 1-gen-2014 | Pisanu, Augusta; Lecca, Daniela; Mulas, Giovanna; Wardas, Jadwiga; Simbula, Gabriella; Spiga, Saturnino; Carta, Annarosa | NEUROBIOLOGY OF DISEASE | - |
Mild Synthetic Approach to Novel Indole-1-Carbinols and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells | 1-gen-2012 | Zedda, G; Simbula, G; Begala, M; Pibiri, M; Floris, C; Casu, M; Casu, L; Tocco, G | ARCHIV DER PHARMAZIE | - |
NOVEL 1-[1-(1H-INDOL-3-YL)ALKYL]-1H-INDOLES AND INDOLE-1-CARBINOLS: SYNTHESIS AND EVALUATION OF CYTOTOXICITY IN HEPATOCARCINOMA CELLS. | 1-gen-2010 | Tocco, Graziella; Zedda, G; Simbula, Gabriella; Pibiri, G; Casu, Mariano; Floris, Costantino; Podda, G; Begala, Michela | - | - |
Comparison of tetraacetylethylendiamine + sodium perborate and sodium hypochlorite cytotoxicity on L929 fibroblasts | 1-gen-2010 | Simbula, Gabriella; Dettori, Claudia; Camboni, Tania; Cotti, Elisabetta | JOURNAL OF ENDODONTICS | - |
Alpha-lipoic acid promotes the growth of rat hepatic preneoplastic lesions in the choline deficient model | 1-gen-2008 | Perra, Andrea; Pibiri, Monica; Sulas, P; Simbula, Gabriella; Ledda, GIOVANNA MARIA; Columbano, Amedeo | CARCINOGENESIS | - |
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats | 1-gen-2008 | Perra, Andrea; Simbula, Gabriella; Simbula, M; Pibiri, Monica; Kowalik, MARTA ANNA; Sulas, P; Cocco, Mt; Ledda, GIOVANNA MARIA; Columbano, Amedeo | THE FASEB JOURNAL | - |
ALFA-LIPOIC ACID ENHANCES CHOLINE DEFICIENT DIET-INDUCED FATTY LIVER AND STEATOHEPATITIS, AND PROMOTES THE GROWTH OF PRENEOPLASTIC LESIONS IN RAT LIVER. POSTER EASL | 1-gen-2007 | Perra, Andrea; Simbula, Gabriella; Pibiri, Monica; Sulas, P; LEDDA COLUMBANO G., M; Columbano, A. | - | - |
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells | 1-gen-2007 | Simbula, Gabriella; Columbano, Amedeo; Ledda, GIOVANNA MARIA; Sanna, L; Deidda, M; Diana, Andrea; Pibiri, Monica | APOPTOSIS | - |
The peroxisome proliferator BR931 kills FaO cells by p53-dependent apotosis | 1-gen-2004 | Simbula, Gabriella; Pibiri, Monica; L., Sanna; C., Cossu; F., Molotzu; Columbano, Amedeo; Ledda, GIOVANNA MARIA | LIFE SCIENCES | - |
Induction of hepatocyte proliferation by retinoic acid | 1-gen-2004 | Ledda, GIOVANNA MARIA; Pibiri, Monica; Molotzu, F; Cossu, C; Sanna, L; Simbula, Gabriella; Perra, Andrea; Columbano, Amedeo | CARCINOGENESIS | - |
Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand TCPOBOP | 1-gen-2003 | Ledda, GIOVANNA MARIA; Pibiri, Monica; Concas, D.; Molotzu, F.; Simbula, Gabriella; Cossu, C.; Columbano, Amedeo | CARCINOGENESIS | - |
Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes | 1-gen-2001 | Ishigami, T; Fujita, T; Simbula, Gabriella; Columbano, Amedeo; Kikuchi, K; Ishigami, A; Shimosawa, T; Arakawa, Y; Maruyama, N. | PATHOLOGY INTERNATIONAL | - |
Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3) | 1-gen-2001 | Pibiri, Monica; Ledda, GIOVANNA MARIA; Cossu, C; Simbula, Gabriella; Menegazzi, M; Shinozuka, H; Columbano, Amedeo | THE FASEB JOURNAL | - |
Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition in cultured hepatocytes | 1-gen-1997 | Simbula, Gabriella; P. A., GLASCOTT JR; S., Akita; J. B., Hoek; J. L., Farber | AMERICAN JOURNAL OF PHYSIOLOGY | - |
The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition | 1-gen-1996 | J. G., Pastorino; Simbula, Gabriella; K., Yamamoto; P. A., GASCOTT JR; R. J., Rothman; J. L., Farber | THE JOURNAL OF BIOLOGICAL CHEMISTRY | - |
Dexametasone inhibits induction of liver Tumor Necrosis Factor-a mRNA and liver growth induced by lead nitrate and ethylene dibromide | 1-gen-1994 | Ledda, GIOVANNA MARIA; Columbano, Amedeo; A., Cannas; Simbula, Gabriella; K., Okita; K., Kayano; Y., Kubo; S. L., Katyal; H., Shinozuka | THE AMERICAN JOURNAL OF PATHOLOGY | - |
Protoporphirine IX, an endogenous ligand of th peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone | 1-gen-1994 | J. G., Pastorino; Simbula, Gabriella; E., Gilfor; J. B., Hoek; J. L., Farber | THE JOURNAL OF BIOLOGICAL CHEMISTRY | - |
Proliferazione cellulare ed epatocarcinogenesi chimica | 1-gen-1994 | Simbula, Gabriella; A., Cannas; A., Columbano | - | - |
DEXAMETHASONE INHIBITS INDUCTION OF LIVER-TUMOR NECROSIS FACTOR-ALPHA MESSENGER-RNA AND LIVER GROWTH INDUCED BY LEAD NITRATE AND ETHYLENE DIBROMIDE | 1-gen-1994 | Ledda, GIOVANNA MARIA; Columbano, Amedeo; Cannas, A; Simbula, Gabriella; Okita, K; Kayano, K; Kubo, Y; Katyal, Sl; Shinozuka, H. | THE AMERICAN JOURNAL OF PATHOLOGY | - |
Compensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis | 1-gen-1993 | Ledda, GIOVANNA MARIA; Coni, Pierpaolo; Simbula, Gabriella; Zedda, I; Columbano, Amedeo | ENVIRONMENTAL HEALTH PERSPECTIVES | - |
Differences in the steady-state levels of c-fos, c-jun and c-myc messanger RNA during mitogen-induced liver growth and compensatory regeneration | 1-gen-1993 | Coni, Pierpaolo; Simbula, Gabriella; DE PRATI, Ac; Menegazzi, M; Suzuki, H; Sarma, Ds; Ledda, GIOVANNA MARIA; Columbano, Amedeo | HEPATOLOGY | - |
Different effects of regenerative and direct mitogenic stimuli on the growth of initiated cells in the resistant hepatocyte model | 1-gen-1993 | Coni, Pierpaolo; PICHIRI CONI, G; Curto, M; Simbula, Gabriella; Giacomini, L; Sarma, Ds; Ledda, GIOVANNA MARIA; Columbano, Amedeo | JAPANESE JOURNAL OF CANCER RESEARCH | - |
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