Università degli Studi di Cagliari
Micaela Morelli
Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice
2023-01-01 Costa, Giulia; Serra, Marcello; Maccioni, Riccardo; Antonietta Casu, Maria; Kasture, Sanjay B.; Acquas, ELIO MARIA GIOACCHINO; Morelli, Micaela
Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients
2023-01-01 Di Maio, Anna; Nuzzo, Tommaso; Gilio, Luana; Serra, Marcello; Buttari, Fabio; Errico, Francesco; De Rosa, Arianna; Bassi, Mario Stampanoni; Morelli, Micaela; Sasabe, Jumpei; Sulzer, David; Carta, Manolo; Centonze, Diego; Usiello, Alessandro
Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration
2023-01-01 Serra, M.; Di Maio, A.; Bassareo, V.; Nuzzo, T.; Errico, F.; Servillo, F.; Capasso, M.; Parekh, P.; Li, Q.; Thiolat, M. -L.; Bezard, E.; Calabresi, P.; Sulzer, D.; Carta, M.; Morelli, M.; Usiello, A.
Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson’s disease
2022-01-01 Parekh, PATHIK HITESHBHAI; Serra, Marcello; Allaw, Mohamad; Perra, Matteo; Marongiu, Jacopo; Tolle, Giulia; Pinna, Annalisa; Antonietta Casu, Maria; Manconi, Maria; Caboni, Pierluigi; Manzoni, Olivier J. J.; Morelli, Micaela
D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
2022-01-01 Florio, Ermanno; Serra, Marcello; Lewis Robert, G; Kramár, Enikö; Freidberg, Michael; Wood, Marcello; Morelli, Micaela; Borrelli, Emiliana
Effects of docosanyl ferulate, a constituent of Withania somnifera, on ethanol- and morphine-elicited conditioned place preference and ERK phosphorylation in the accumbens shell of CD1 mice
2022-01-01 Maccioni, R.; Serra, M.; Marongiu, J.; Cottiglia, F.; Maccioni, E.; Bassareo, V.; Morelli, M.; Kasture, S. B.; Acquas, E.
Why is fake news so fascinating to the brain?
2022-01-01 Grignolio, Andrea; Morelli, Micaela; Tamietto, Marco
Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences
2021-01-01 Costa, G.; Caputi, F. F.; Serra, M.; Simola, N.; Rullo, L.; Stamatakos, S.; Sanna, F.; Germain, M.; Martinoli, M. -G.; Candeletti, S.; Morelli, M.; Romualdi, P.
Protective Agents in Parkinson’s Disease: Caffeine and Adenosine A2A Receptor Antagonists
2021-01-01 Simola, Nicola; Pinna, Annalisa; Frau, Lucia; Costa, Giulia; Marongiu, Jacopo; Parekh, Pathik; Serra, Marcello; Morelli, Micaela
Increased emissions of 50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs: A potential preclinical model for studying the affective properties of dopamine replacement therapy in Parkinson's disease
2021-01-01 Simola, Nicola; Serra, Marcello; Marongiu, Jacopo; Costa, Giulia; Morelli, Micaela
Neuroinflammation and L-dopa-induced abnormal involuntary movements in 6-hydroxydopamine-lesioned rat model of Parkinson's disease are counteracted by combined administration of a 5-HT1A/1B receptor agonist and A2A receptor antagonist
2021-01-01 Pinna, A.; Costa, G.; Serra, M.; Contu, L.; Morelli, M.
In utero exposure to dexamethasone causes a persistent and age-dependent exacerbation of the neurotoxic effects and glia activation induced by MDMA in dopaminergic brain regions of C57BL/6J mice
2021-01-01 Costa, G.; Spulber, S.; Paci, E.; Casu, M. A.; Ceccatelli, S.; Simola, N.; Morelli, M.
Involvement of the protein ras homolog enriched in the striatum, rhes, in dopaminergic neurons’ degeneration: Link to parkinson’s disease
2021-01-01 Serra, M.; Pinna, A.; Costa, G.; Usiello, A.; Pasqualetti, M.; Avallone, L.; Morelli, M.; Napolitano, F.
Influence of dopamine transmission in the medial prefrontal cortex and dorsal striatum on the emission of 50-kHz ultrasonic vocalizations in rats treated with amphetamine: Effects on drug-stimulated and conditioned calls
2020-01-01 Costa, Giulia; Serra, Marcello; Marongiu, Jacopo; Morelli, Micaela; Simola, Nicola
Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease
2020-01-01 Vascellari, Sarah; Palmas, Vanessa; Melis, Marta; Pisanu, Silvia; Cusano, Roberto; Uva, Paolo; Perra, Daniela; Madau, Veronica; Sarchioto, Marianna; Oppo, Valentina; Simola, Nicola; Morelli, Micaela; Santoru, Maria Laura; Atzori, Luigi; Melis, Maurizio; Cossu, Giovanni; Manzin, Aldo
Genetic variants of TAS2R38 bitter taste receptor associate with distinct gut microbiota traits in Parkinson's disease: A pilot study
2020-01-01 Vascellari, Sarah; Melis, Melania; Cossu, Giovanni; Melis, Marta; Serra, Alessandra; Palmas, Vanessa; Perra, Daniela; Oppo, Valentina; Fiorini, Michele; Cusano, Roberto; Morelli, Micaela; Manzin, Aldo; Barbarossa, Iole Tomassini
Gender Differences in Neurodegeneration, Neuroinflammation and Na+-Ca2+ Exchangers in the Female A53T Transgenic Mouse Model of Parkinson’s Disease
2020-01-01 Costa, Giulia; Sisalli, Maria Jose; Simola, Nicola; Della Notte, Salvatore; Casu, Maria Antonietta; Serra, Marcello; Pinna, Annalisa; Feliciello, Antonio; Annunziato, Lucio; Scorziello, Antonella; Morelli, Micaela
Neuroinflammation and activation of Zif-268 in dyskinetic 6-OHDA-lesioned rats is counteracted by association of a 5-HT1A/1B receptor agonist and an A2A receptor antagonist
2019-01-01 Pinna, A; Costa, G; Serra, M.; Morelli, M
Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
2019-01-01 Costa, Giulia; Porceddu, Pier Francesca; Serra, Marcello; Casu, Maria Antonietta; Schiano, Valentina; Napolitano, Francesco; Pinna, Annalisa; Usiello, Alessandro; Morelli, Micaela
Combined administration of dopaminergic and nondopaminergic drugs reverses neuroinflammation in a rat model of Parkinson’s disease
2019-01-01 Costa, G; Serra, M.; Morelli, M.; Pinna, A
Odor identification performance in idiopathic Parkinson’s disease is associated with gender and the genetic variability of the olfactory binding protein
2019-01-01 Melis, M.; Sollai, G.; Masala, C.; Pisanu, C.; Cossu, G.; Melis, M.; Sarchioto, M.; Oppo, V.; Morelli, M.; Crnjar, R.; Hummel, T.; Barbarossa, I.
Rhes counteracts dopamine neuron degeneration and neuroinflammation depending on gender and age
2018-01-01 Costa, Giulia; Pinna, Annalisa; Porceddu, Pier Francesca; Casu, Maria Antonietta; Di Maio, Anna; Napolitano, Francesco; Usiello, Alessandro; Morelli, Micaela
Neurochemical and neurotoxic effects of MDMA (Ecstasy) and caffeine after chronic combined administration in mice
2018-01-01 Górska, Anna Maria; Kamińska, Katarzyna; Wawrzczak-Bargieła, Agnieszka; Costa, Giulia; Morelli, Micaela; Przewłocki, Ryszard; Kreiner, Grzegorz; Gołembiowska, Krystyna
Role of adenosine A2A receptors in motor control: relevance to Parkinson’s disease and dyskinesia
2018-01-01 Pinna, Annalisa; Serra, Marcello; Morelli, Micaela; Simola, Nicola
Repeated Administration of 3,4-Methylenedioxymethamphetamine (MDMA) Elevates the Levels of Neuronal Nitric Oxide Synthase in the Nigrostriatal System: Possible Relevance to Neurotoxicity
2018-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson's Disease
2018-01-01 Sirabella, Rossana; Sisalli, Maria Josè; Costa, Giulia; Omura, Katia; Ianniello, Gaetano; Pinna, Annalisa; Morelli, Micaela; Di Renzo, Gianfranco Maria; Annunziato, Lucio; Scorziello, Antonella
Modulation of rat 50-kHz ultrasonic vocalizations by glucocorticoid signaling: possible relevance to reward and motivation
2018-01-01 Simola, Nicola; Paci, Elena; Serra, Marcello; Costa, Giulia; Morelli, Micaela
6-n-propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease
2018-01-01 Cossu, Giovanni; Melis, Melania; Sarchioto, Marianna; Melis, Marta; Melis, Maurizio; Morelli, Micaela; Tomassini Barbarossa, Iole
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
2017-01-01 Moratalla, Rosario; Khairnar, Amit; Simola, Nicola; Granado, Noelia; García Montes, Jose Ruben; Porceddu, PIER FRANCESCA; Tizabi, Yousef; Costa, Giulia; Morelli, Micaela
Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage
2017-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
Role of Adenosine in the basal Ganglia
2017-01-01 Morelli, Micaela; Simola, Nicola; Popoli, P.; Carta, Annarosa
Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques
2017-01-01 Napolitano, Francesco; Warren, Emily Booth; Migliarini, Sara; Punzo, Daniela; Errico, Francesco; Li, Qin; Thiolat, Marie-Laure; Vescovi, Angelo Luigi; Calabresi, Paolo; Bezard, Erwan; Morelli, Micaela; Konradi, Christine; Pasqualetti, Massimo; Usiello, Alessandro
A preclinical study on the combined effects of repeated eltoprazine and preladenant treatment for alleviating L-DOPA-induced dyskinesia in Parkinson's disease
2017-01-01 Ko, Wai Kin D.; Li, Qin; Cheng, Long Yun; Morelli, Micaela; Carta, Manolo; Bezard, Erwan
Metformin prevented dopaminergic neurotoxicity induced by 3,4-Methylenedioxymethamphetamine administration
2016-01-01 Porceddu, PIER FRANCESCA; Ishola, Io; Contu, Liliana; Morelli, Micaela
Effect of crowding, temperature and age on glia activation and dopaminergic neurotoxicity induced by MDMA in the mouse brain
2016-01-01 Frau, Lucia; Simola, Nicola; Porceddu, PIER FRANCESCA; Morelli, Micaela
Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's disease
2016-01-01 Pinna, Annalisa; Ko, Wkd; Costa, Giulia; Tronci, Elisabetta; ALVAREZ FIDALGO, Camino; Simola, Nicola; Li, Q; Tabrizi, Ma; Bezard, E; Carta, Manolo; Morelli, Micaela
Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease
2016-01-01 Baranyi, M; Porceddu, PIER FRANCESCA; Goloncser, F; Kulcsar, S; Otrokocsi, L; Kittel, A; Pinna, Annalisa; Frau, Lucia; Huleatt, P. b.; Khoo, Ml; Chai, C. l. l.; Dunkel, P; Matyus, P; Morelli, Micaela; Sperlagh, B.
Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent
2016-01-01 Frau, Lucia; Costa, Giulia; Porceddu, Pier Francesca; Khairnar, Amit; Castelli, Maria Paola; Ennas, Maria Grazia; Madeddu, Camilla; Wardas, Jadwiga; Morelli, Micaela
Methylxanthines and drug dependence: interactions and toxicity
2016-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
Gender-dependent behavioral and biochemical differences in the A53T genetic mouse model of Parkinson’s disease
2016-01-01 Costa, G.; Sisalli, M. J.; Contu, L.; Scorziello, A.; Morelli, M.
Activation of adenosine A2A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation
2016-01-01 Simola, Nicola; Costa, Giulia; Morelli, Micaela
The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging
2016-01-01 Pinna, Annalisa; Napolitano, F; Pelosi, B; Di Maio, A; Wardas, J; Casu, Ma; Costa, Giulia; Migliarini, S; Calabresi, P; Pasqualetti, M; Morelli, Micaela; Usiello, A.
The small GTP-binding protein Rhes influences midbrain dopaminergic neurons: Behavioral and biochemical studies
2016-01-01 Pinna, A.; Napolitano, F.; Costa, G.; Porceddu, P. F.; Contu, L.; Wardas, J.; Casu, M. A.; Usiello, A.; Morelli, M.
Preface [ to The Adenosinergic System. A Non-Dopaminergic Target in Parkinson’s Disease]
2015-01-01 Morelli, Micaela; Simola, Nicola; Wardas, J.
Involvement of Glutamate NMDA Receptors in the Acute, Long-Term, and Conditioned Effects of Amphetamine on Rat 50kHz Ultrasonic Vocalizations
2015-01-01 Costa, Giulia; Morelli, Micaela; Simola, Nicola
Repeated amphetamine administration and long-term effects on 50-kHz ultrasonic vocalizations: possible relevance to the motivational and dopamine-stimulating properties of the drug
2015-01-01 Simola, Nicola; Morelli, Micaela
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
2015-01-01 Bastide, Mf; Meissner, Wg; Picconi, B; Fasano, S; Fernagut, Po; Feyder, M; Francardo, V; Alcacer, C; Ding, Ym; Brambilla, R; Fisone, G; Stoessl, Aj; Bourdenx, M; Engeln, M; Navailles, S; De Deurwaerdere, P; Ko, Wkd; Simola, Nicola; Morelli, Micaela; Groc, L; Rodriguez, Mc; Gurevich, Ev; Quik, M; Morari, M; Mellone, M; Gardoni, F; Tronci, Elisabetta; Guehl, D; Tison, F; Crossman, Ar; Kang, Uj; Steece Collier, K; Fox, S; Carta, Manolo; Cenci, Am; Bezard, E.
Antagonism of Adenosine A1 or A2A Receptors Amplifies the Effects of 3,4-Methylendioxymethamphetamine (MDMA) on Glial Activation in the Mouse Brain: Relevance to Caffeine-MDMA Interactions
2014-01-01 Khairnar, A; Frau, Lucia; Plumitallo, Antonio; Morelli, Micaela; Simola, Nicola
Effect of memantine on L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease.
2014-01-01 Tronci, Elisabetta; ALVAREZ FIDALGO, Camino; Zianni, E; Collu, Maria; Stancampiano, Roberto; Morelli, Micaela; Gardoni, F; Carta, Manolo
Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions
2014-01-01 Heumann, R; Moratalla, R; HERRERO M., T; Chakrabarty, K; DRUCKER COLIN, R; GARCIA MONTES J., R; Simola, Nicola; Morelli, Micaela
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