Dipartimento di Scienze della vita e dell’ambiente

Short CV
Antonio Lupia was born in Catanzaro (Italy) on March 7th, 1989. In 2015, he received a degree in Pharmacy at the University "Magna Græcia" of Catanzaro (Italy), discussing an experimental thesis in computational chemistry titled "Identification of new selective bioactive ligands for phospho-tyrosine-phosphatase 1B"  under the supervision of Prof Anna Artese. During this time, he worked in the Molecular Design Lab group at the Frëie University of Berlin - Institute of Pharmacy – in Gerhard Wolber's Lab.

In 2019, at the University Magna Græcia of Catanzaro, he reached a PhD degree in Life Sciences defending a thesis entitled "Molecular modelling of epitopes recognised by neoplastic B-cells in Chronic Lymphocytic Leukemia (CLL)", also receiving the Paul Ehrlich Euro-PhD award. Antonio has been deeply involved in in-silico computational analysis of epitopic reactivity of tumour B cell clones in Chronic Lymphocytic Leukaemia (CLL) by first analysing the structure of the idiotypic region of the B cell receptor (BCR), then by identifying the common chemical features of the peptides recognised by different CLL IgBCR, so-called cross-reactive (CR) Id-peptides (DOI: 10.1016/j.ejmech.2019.111838). During the PhD training program, he spent seven months at the Institute of Oncology Research (IOR) of Bellinzona, Switzerland, under the supervision of Dr Francesco Bertoni and Dr Eugenio Gaudio. Here, he acquired knowledge of new bioinformatics tools, including a novel algorithm for Detecting the Mechanism of Action-based Network Dysregulation (DeMAND). Associated with the bioinformatic tool, he used in-silico computational methods to study tumour targets for promising ligands.

The scientific interests concern the application of computational methods, including Pharmacophore, Molecular Docking, 3D-QSAR,  Molecular Dynamics and Virtual Screening techniques, as well as a great interest in the study and application of processes based on Machine Learning (ML) to investigate the drug-receptor interactions, design and lead-optimisation of potential drugs. Further interests are related to assessing complex and atypical ligands/targets, such as protein-protein interactions or peptide-antibody. To date, the main research interest is focused on all Flaviviridae family (DENV 1-2-3-4), ZIKA, WNV, YFV, and in particular, NS3-NS3B protease complex, which has been established as a valuable target for drug design to treat all flavivirus infections.
Antonio has collaborated with prestigious international research teams both in research-related Projects and as part of the Organizer Committee of national/international meetings.
He is a co-founder of the Net4Science academic spinoff.
All this underlines high flexibility and team-based workability chiefly in dynamic and changing circumstances, but always with a remarkable scientific curiosity.


Titoli di studio e carriera

01/03/2023
Ricercatore universitario a t.d. tipo A (RTDA)

16/12/2022
Master Universitario di II livello – Luiss Business School
Master in Management della Filiera della Salute
Major in Sperimentazione Clinica: aspetti regolatori, gestionali, operativi

• Assetti Istituzionali e Sistemi di finanziamento
• Aspetti normativi e regolatori
• Pianificazione di uno studio clinico
• Il percorso autorizzativo di uno studio clinico
• Gestione e conduzione degli studi Clinici
• Monitoraggio e controllo degli studi clinici
• Analisi dei risultati

Supervisor Dott.re Gianfranco De Feo, Dirigente della Direzione Scientifica I.N.T. Fondazione G. Pascale (Napoli)
Dott.re Fabrizio Galliccia, Dirigente di I livello delle professionalità sanitarie – Ispettore Senior GCP presso AIFA.

Dal 01-10-2022 al 28-02-2023
Postdoctoral Research (CHIM08)
Università degli Studi di Napoli “Federico II”
Responsabile Scientifico Prof Bruno Catalanotti

Dal 01-10-2021 al 30-09-2022
Postdoctoral Research (CHIM08)

Università degli Studi di Napoli “Federico II”
Responsabile Scientifico Prof Vittorio Limongelli

Dal 01-08-2019 al 31-03-2021
Ricercatore e co-founder dello spinoff Net4Science srl (N4S)
c/o Università “Magna Græcia” di Catanzaro
Campus Universitario “S. Venuta”, Viale Europa, 88100, (CZ)
CEO spinoff Prof. Francesco Ortuso
Responsabile Scientifico Prof. Stefano Alcaro

05/04/2019
Dottore di ricerca (PhD)
Titolo della tesi: "Molecular modelling of epitopes recognised by neoplastic B-cells in Chronic Lymphocytic Leukemia (CLL)”

Dal 31-01-2018 al 31-07-2018
Visiting PhD Student
c/o Istituto Oncologico di Ricerca (IOR)
Via Vincenzo Vela 6, 6500, Bellinzona, (CH)
Supervisor Dr. Francesco Bertoni & Dr. Eugenio Gaudio

Dal 05-11-2015 al 30-11-2018
Dottorato di Ricerca in Scienza della Vita - Curriculum Biotecnologico
Università degli Studi “Magna Græcia” di Catanzaro
Supervisor Prof.ssa Ileana Quinto

22/10/2015
Laurea in Farmacia
Università degli Studi "Magna Graecia" di Catanzaro
Titolo della tesi: "Identification of new selective bioactive ligands for Phospho-Tyrosine-Phosphatase 1B” 
Supervisor Prof.ssa Anna Artese

01/02/14 to 31/07/2014
Guest Researcher

Institut für Pharmazie, Pharmazeutische und Medizinische Chemie
Computergestütztes Wirkstoffdesign, Königin-Luise-Str. 2 + 4 in 14195, Berlin
Prof. Gherard Wolber, Dr. Alexandra Naß e Dr. Jamil Al-Asri                               

11/07/2008
Diploma di Maturità Classica
Liceo Classico “P. Galluppi”, Catanzaro


Trasferimento Tecnologico
Socio fondatore dello spinoff accademico Net4Science srl (N4S)
c/o Università “Magna Græcia” di Catanzaro, Campus Universitario “S. Venuta”, Viale Europa, 88100, Catanzaro
Codice Fiscale/P.IVA: 0366606079
Registro delle Imprese di CATANZARO (IT)
Data atto di costituzione: 18-12-2018
Iscritta nella sezione ORDINARIA il 27-12-2018
Iscritta nell’apposita sezione speciale in qualità di STARTUP INNOVATIVA il 27-12-2018


Premi e Riconoscimenti

  • Paul Ehrlich Euro-PhD Award (www.pehrlichmedchem.eu)
  • ANGI Award 2020 – “Associazione Nazionale Giovani Innovatori”.

Informazioni aggiuntive

·         Researchgate
·         Twitter
·         Linkedin
·         Orcid


Skill Highlights
• Knowledge of computational techniques in the Drug Discovery process
• Excellent command of molecular modelling software (Schrödinger suite, LigandScout, AMBER, Autodock, FLAP, KNIME)
• Good knowledge of programming languages (Python, PHP, JavaScript, and HTML editing)
• Excellent skills with Adobe Illustrator, CyberLink Power Director and others related to Photo/Video/Music editing
• Excellent command of Microsoft Windows OS, Linux OS and Mac OS

Soft skills:
• Professionalism, coherence, and respect
• Creativity and attention to detail
• High flexibility and adaptation in a new context
• High problem-solving skills, motivation, and goal bearings

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