Dipartimento di Scienze della Vita e dell’Ambiente

DATE AND PLACE OF BIRTH

  • November 4, 1959 - Leghorn (Italy)

EDUCATION

  • 1978-1982 - M.S. in Biology (2-18-1983) University of Pisa;
  • 1983-1987 - Ph.D. in Physical Anthropology (10-5-1987) University of Florence.

ACADEMIC EMPLOYMENTS (place, date and position):

  • University of Pisa, Institute of Anthropology (1983-1987): post-graduate
  • University of Cape Town, Dept. of Archaeology (1988): post-doc, Director: A. Sillen
  • University of Pisa, Institute of Anthropology (1989-1990): contract research assistant
  • University of Stanford, Dept. of Genetics (1991-1992): research assistant, Director: LL. Cavalli-Sforza
  • University of Sassari, Dept. of Zoology and Biological Anthropology (1992-2003): Researcher in Physical Anthropology
  • University of Sassari, Dept. of Biomedical Sciences (2004-2018): Professor of Genetics
  • University of Caglairi, Dept. of Environmental and Life Sciences (2018 - present): Professor of Genetics 

TEACHING ACTIVITY

  • 1995 to 2004 - Temporary Professor of Anthropology for Natural Sciences and Biological Sciences.
  • 1996 to 2004 -Temporary Professor of Population Genetics for Environmental Sciences (up to 2000) and Natural Sciences
  • 2004 to present - Titular Professor of Genetics Molecular Genetics and Population Genetics for Biological Sciences, Natural Sciences and Biotechnology
  • 2008-2015 - Visiting professor for the Masters in Molecular Biomedicine, University of Alicante
  • 2016-2018 - Visiting professor for the Master in Medical Biotechnologies, University of Hue (Vietnam)
  • Director of about 100 bachelor and master thesis in Natural Sciences, Biological Sciences, Environmental Sciences
  • Director of 2 Doctoral thesis in Human Population Genetics (Università di Sassari)
  • Co-director of 1 Doctoral thesis in Physical Anthropology (Universitat Autonoma de Barcelona)

INVITED SPEAKER

  • Invited speaker for seminars, conferences, summer schools and courses at the following universities and academic institutions, national and international: Italian universities: Pisa, Florence, Turin, Milan, Insubria (Varese), Bologna, Rome "Tor Vergata", Cagliari, Bari, Palermo, Messina; Foreign universities: Harvard-MIT, Philadelphia, Princeton-IAS (USA), Göttingen, Mainz (Germany), Barcelona, Autonomous of Barcelona, Alicante (Spain), Komotini (Greece), Court (France), Wroclaw (Poland), Ponta Delgada (Portugal); Scientific institutions: Natural History Museum of Verona, Livorno, Pavia, Museo Etnografico “Pigorini”, Roma. National Institute of Health (Rome)

RESEARCH INTERESTS

  • Analysis of mitochondrial DNA and Y chromosome in human populations
  • Analysis of DNA from ancient tissues
  • Surname analysis
  • Molecular phylogeny and Population genetics of various vertebrate, invertebrate and microbial species

EDITORIAL ACTIVITY

  • Associated editor of BMC Evolutionary Biology
  • Reviewer for the following journals: Annals of Human Genetics, Human Biology, PLoS Biology, BMC Genomics, Human Mutations, GigaScience, and others.

PROFESSIONAL SOCIETY MEMBERSHIPS

  • Associazione Genetica Italiana (AGI)
  • Società Italiana di Biologia Evoluzionistica (SIBE)
  • Associazione Antropologi Italiani (AAI)

RESEARCH ACTIVITY

  • Participation in national and international scientific projects:
  • 1989-1990 Collaborator to the project between Italy and Spain (Integrated Actions): "Comparative study of methodologies for the paleodietary analysis". In collaboration with the Universitat Autónoma de Barcelona.
  • 1992-1993 Local coordinator of the CNR project " Biological Archive: subproject Anthropology
  • 1997 Italian-Spanish project (Integrated Actions): "Analysis of mitochondrial DNA in ancient Mediterranean populations" In collaboration with the Universitat Autónoma de Barcelona.
  • 1997-1999 Participant to the CNR project “Biological Archive" coordinated by L.Terrenato
  • 1998-2003 Collaborator to the project PRIN coordinated by G. De Stefano.
  • 1999-2003 Participant to the Interreg project with the University of Corte (Corsica)
  • 2000-2006 Collaborator at the Centre of Excellence set up at the University of Sassari
  • 2003-2005 Collaborator to the project Interreg III with the University of Corte (Corsica), Cagliari (Sardinia) and Pisa (Tuscany)
  • 2010-2011 Head of project RAS "High resolution phylogeny of the human Y chromosome"

CONGRESS ORGANIZING ACTIVITY

  • 11-12 / 3/2000 Irgoli (NU) - Organization of the national meeting: "Irgoli: biodemography and population genetics using surnames"
  • 2-5 / 10/2008 Alghero (SS) Organization of the international congress of the Italian Society of Evolutionary Biology (SIBE)

LINGUISTIC KNOWLEDGE

  • Italian = mother tongue
  • English = fluent
  • Spanish = fluent
  • French = good

SELECTED PUBLICATIONS

  • LL Huber, E Arango-Isaza, JR Sandoval, M Urban, P Francalacci, C Calò, E Macholdt, M Stoneking, L Roewer, M Seidel, O Acosta, R Fujita, KK Shimizu, C Barbieri (2025) Human population history on the North Coast of Peru from Y chromosomes and mitogenomes. SCIENTIFIC REPORTS 15:27362. 
  • Y Tian, I Koncz, S Defant, C Giostra, DN Vyas, A Soltysyak, L Pejrani Baricco, R Fetner, C Posth, G Brandt, E Bedini, A Modi, M Lari, S Vai, P Francalacci, R Fernandes, A Steinhof, W Pohl, D Caramelli, J Krause, A Izdebski, PJ Geary, KR Veeramah (2024) The role of emerging elites in the formation and development of communities after the fall of the Roman Empire. PROCEEDINGS OF THE NATIONAL ACCADEMY OF SCIENCES 121 (36) e2317868121
  • L Di Pietro, M Boroumand, W Lattanzi, B Manconi, M Salvati, T Cabras, A Olianas, L Flore, S Serrao, CM Calò, P Francalacci, O Parolini, M Castagnola (2023) A catalog of coding sequence variations in salivary proteins’ genes occurring during recent human evolution. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24:15010 
  • DN Vyas, I Koncz, A Modi, BG Mende, Y Tian, P Francalacci, M Lari, S Vai, P Straub, Z Gallina, T Szeniczey, T Hajdu, L Pejrani Baricco, C Giostra, R Radzeviciute, Z Hofmanova, S Evinger, Z Bernert, W Pohl, D Caramelli, T Vida, PJ Geary, KR Veeramah (2023) Fine-scale sampling uncovers the complexity of migrations in 5th–6th century Pannonia. CURRENT BIOLOGY 33:3951–3961
  • L Flore, P Francalacci, M Massidda, R Robledo, CM Calò (2023) Influence of Different Evolutive Forces on GDF5 Gene Variability. GENES 14:1895
  • CEG. Amorim, S Vai, C Posth, Al Modi, I Koncz, S Hakenbeck, MC La Rocca, B Mende, D Bobo, W Pohl, L Pejrani Baricco, E Bedini, P Francalacci, C Giostra, T Vida, D Winger, U von Freeden, S Ghirotto, M Lari, G Barbujani, J Krause, D Caramelli, PJ Geary, KR Veeramah (2018) Understanding 6th-century barbarian social organization and migration through paleogenomics. NATURE COMMUNICATIONS 9:3547
  • P Anagnostou, V Dominici, C Battaggia, L Pagani, M Vilar, RS Wells, D Pettener, S Sarno, A Boattini, P Francalacci, V Colonna, G Vona, CM Calò, G Destro Bisol, S Tofanelli (2017) Overcoming the dichotomy between open and isolated populations using genomic data from a large European dataset. SCIENTIFIC REPORTS 7: 41614
  • M Simón, N Díaz, E Solórzano, R Montiel, P Francalacci, A Malgosa (2017) Dissecting mitochondrial dna variability of balearic populations from the bronze age to the current era. AMERICAN JOURNAL OF HUMAN BIOLOGY 29:  e22883
  • P. Francalacci, D. Sanna, A. Useli, R. Berutti, M. Barbato, M. B Whalen, A. Angius, C. Sidore, S. Alonso, S. Tofanelli, F. Cucca (2015) Detection of phylogenetically informative polymorphisms in the entire euchromatic portion of human Y chromosome from a Sardinian sample. BMC RESEARCH NOTES 8 (1), 174
  • S.Tofanelli, L.Taglioli, S.Bertoncini, P. Francalacci, A.Klyosov, L.Pagani (2014) Mitochondrial and Y chromosome haplotipe motifs as diagnostic markers od Jewish ancestry: a reconsideration. FRONTIERS IN GENETICS doi:10.3389/gene2014.00384
  • E. Elhaik, T Tatarinova, D Chebotarev, IS. Piras, CM Calò, A De Montis, M Atzori, M Marini, S Tofanelli, P. Francalacci, L Pagani, C Tyler-Smith, Y Xue, F Cucca, TG. Schurr, JB. Gaieski, C. Melendez, MG. Vilar, AC. Owings, R. Gomez, R. Fujita, F.Santos, D Comas, O Balanovsky, E Balanovska, P Zalloua, H Soodyall, R Pitchappan, A GaneshPrasad, M Hammer, SR.Wells, and the Genographic Consortium (2014) Geographic Population Structure (GPS) of worldwide human populations infers biogeographical origin down to home village. NATURE COMMUNICATIONS. DOI:10.1038/ncomms4513
  • M. Capocasa, P. Anagnostou, V. Bachis, C. Battaggia, S. Bertoncini, G. Biondi, A. Boattini, I. Boschi, F. Brisighelli, C.M. Calò, M. Carta, V. Coia, L. Corrias, F. Crivellaro, V. Dominici, G. Ferri, P. Francalacci, Z.A. Franceschi, D. Luiselli, L. Morelli, O. Rickards, R. Robledo, D. Sanna, E. Sanna, S. Sarno, S. Tofanelli, G. Vona, D. Pettener, G. Destro Bisol (2014) Linguistic, geographic and genetic isolation: a collaborative study on Italian populations JOURNAL OF ANTHROPOLOGICAL SCIENCES 92 doi: 10.4436/jass92001
  • P.Francalacci, L.Morelli, A.Angius, R.Berutti, F.Reinier, R.Atzeni, R.Pilu, F.Busonero, A.Maschio, I.Zara, D.Sanna, A.Useli, M.F.Urru, M.Marcelli, R.Cusano, M.Oppo3, M.Zoledziewska, M.Pitzalis, F.Deidda, E.Porcu, F.Poddie, H.M.Kang, R.Lyons, B.Tarrier, J.Bragg Gresham, B.Li, S.Tofanelli, S.Alonso, M.Dei, S.Lai, A.Mulas, M.B.Whalen, S.Uzzau, C.Jones, D.Schlessinger, G.R.Abecasis, S.Sanna, C.Sidore,, F.Cucca (2013) Low pass DNA sequencing of 1,200 Sardinians reconstructs European Y chromosome phylogeny. SCIENCE 341:565-569
  • E. Elhaik, E. Greenspan, S. Staats, T. Krahn, C. Tyler-Smith, Y. Xue, S. Tofanelli, P. Francalacci, F. Cucca, L. Pagani, L. Jin, H. Li, T. G. Schurr, B. Greenspan, R. S. Wells, and the Genographic Consortium. (2013) The GenoChip: A New Tool for Genetic Anthropology. GENOME BIOLOGY AND EVOLUTION, doi:10.1093/gbe/evt066
  • L. Alvarez, C. Santos, A. Ramos, R. Pratdesaba, P. Francalacci, M.P. Aluja (2010) Mitochondrial DNA Patterns in the Iberian Northern Plateau: Population Dynamics and Substructure of the Zamora Province. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY doi: 10.1002/ajpa.21252
  • L. Morelli, D. Contu, F. Santoni, M.B. Whalen, P. Francalacci, F. Cucca (2010) A Comparison of Y-Chromosome Variation in Sardinia and Anatolia is More Consistent with Cultural Rather than Demic Diffusion of Agriculture. PLOS ONE, 5: e10419
  • K. Nalam, A. Ahmed, S. Manjulata Devi, P. Francalacci, M. Baig, L. A. Sechi, R. A. Hartskeerl, N. Ahmed (2010) Genetic Affinities within a Large Global Collection of Pathogenic Leptospira: Implications for Strain Identification and Molecular Epidemiology PLOS ONE 5(8): e12637 doi:10.1371/journal.pone.0012637
  • M. Pala, A. Achilli, A.Olivieri, B. Hooshiar Kashani, U.A. Perego, D. Sanna, E. Metspalu, K. Tambets, E. Tamm, M. Accetturo, V. Carossa, H. Lancioni, F. Panara, B. Zimmermann, G. Huber, N. Al-Zahery, F. Brisighelli, S. R. Woodward, P. Francalacci, W. Parson, A. Salas, D. M. Behar, R. Villems, O. Semino, H-J. Bandelt, A. Torroni (2009) Mitochondrial Haplogroup U5b3: a Distant Echo of the Epipaleolithic in Italy and the Legacy of the Early Sardinians. AMERICAN JOURNAL OF HUMAN GENETICS 86: 814-821
  • D Contu, L Morelli, F Santoni JW. Foster, P.Francalacci, F Cucca (2008) Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans. PLOS ONE
  • P. Francalacci, D. Sanna (2008) History and Geography of human Y-chromosome in Europe: a SNP perspective. JOURNAL OF ANTHROPOLOGICAL SCIENCES, 86: 59-89
  • SM.Devi, I.Ahmed, P.Francalacci, MA Hussain, Y Akhter, A Alvi, LA Sechi, F Mégraud, N Ahmed (2007) Ancestral European roots of Helicobacter pylori in India. BMC GENOMICS 8:184
  • D Caramelli, C Vernesi, S Sanna, L Sampietro, M Lari, L Castrì, G Vona, R Floris, P.Francalacci, R Tykot, A Casoli, J Bertranpetit, C Lalueza-Fox, G Bertorelle, G Barbujani (2007) Genetic variation in prehistoric Sardinia. HUMAN GENETICS
  • C.Santos, R.Montiel, N.Angles, M.Lima, P.Francalacci, A.Malgosa, A.Abade, M.P.Aluja (2004) Determination of human Caucasian mitochondrial DNA haplogroups by means of a hierarchical approach. HUMAN BIOLOGY 76: 431-453
  • P.Francalacci, L.Morelli, P.A.Underhill, A.S.Lillie, G.Passarino, A.Useli, R. Madeddu, G.Paoli, S.Tofanelli, C.M.Calò, M.E.Ghiani, L.Varesi, M.Memmi, G.Vona, P.Oefner, P.Shen, L.L.Cavalli-Sforza (2003) The peopling of three Mediterranean islands (Corsica, Sardinia and Sicily) inferred by Y-chromosome biallelic variability. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 121:270-279
  • D.Contu, L.Morelli, P.Zavattari, R.Lampis, E.Angius, Frongia, D.Murru, M.Maioli, P.Francalacci, J.A. Todd, F. Cucca (2002) Sex related bias and exclusion mapping of the non-recombinant portion of chromosome Y in human type 1 diabetes in the isolated founder population of Sardinia. DIABETES 51: 3573-3576
  • A Torroni, HJ Bandelt,V Macaulay, M Richards, F Cruciani, C Rengo, V Martinez-Cabrera, RVillems, T Kivisild, E Metspalu, JR Parik, HV Tolk, K Tambets, P Forster, B Karger, P Francalacci, P Rudan, B Janicijevic, O Rickards, ML Savontaus, K Huoponen, V Laitinen, SKoivumaki, B Sykes, E Hickey, A Novelletto, P Moral, D Sellitto, A Coppa, N Al-Zaheri, AS Santachiara-Benerecetti, O Semino, R Scozzari (2001) A signal, from human mtDNA, of postglacial recolonization in Europe AMERICAN JOURNAL OF HUMAN GENETICS 69 844-852
  • R.Montiel, A.Malgosa, P.Francalacci (2001) Authenticating ancient human mitochondrial DNA. HUMAN BIOLOGY, 73: 689-713
  • O. Semino, G. Passarino, P.J. Oefner, A.A. Lin, S. Arbuzova, L.E. Beckman, G. De Bendictis, P.Francalacci, S. Limborska, A. Kouvatsi, M. Marcikiae, D. Primorac, S. Santachiara-Benerecetti, L.L. Cavalli-Sforza, P.A. Underhill (2000) The genetic legacy of Palaeolithic Homo sapiens sapiens in extant Europeans: a Y-chromosome perspective. SCIENCE 290:1155-1159 (2000)
  • P.A. Underhill, P. Shen, A.A. Lin, L. Jin, G. Passarino, W.H. Yang, E. Kauffman, A. Hurlbut, B. Bonné-Tamir, J. Bertranpetit, P.Francalacci, M. Ibrahim, T. Jenkins, J.R. Kidd, S.Q. Mehdi, M.T. Seielstad, R.S. Wells, A. Piazza, D. Soergel, S. Sherry, M.W. Feldman, R.W. Davis, L.L. Cavalli-Sforza, and P.J. Oefner.(2000) Y Chromosome variation and the History of human populations. NATURE GENETICS 26:358-361
  • L. Morelli, M.G. Grosso, G.Vona, L.Varesi, A.Torroni, P.Francalacci (2000) Frequency distribution of mitochondrial haplogroups in Corsica and Sardinia. HUMAN BIOLOGY, 72: 585-595
  • P.Francalacci, J.Bertranpetit, F.Calafell, P.A.Underhill. (1996) Sequence diversity of the control region of mitochondrial DNA in Tuscany and its implications for the peopling of Europe. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 100: 443-460
  • A.Torroni, K.Huoponen, P.Francalacci, M.Petrozzi, L.Morelli, R.Scozzari, D.Obinu, M.L.Savontaus, D.C.Wallace. (1996). Classification of European mitochondrial DNA from an analysis of 3 European populations. GENETICS, 144: 18

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