Marital status and long-term cardiovascular risk in general population—RIFLE project (Italy)

Rabiaza, Andry;Puddu, Paolo E.;Menotti, Alessandro;Humbert, Xavier;Menotti, A.;Farchi, G.;Alessandrini, P.;Ambrosio, G. B.;Angelico, F.;Antonini, R.;Attili, F. A.;Avellone, G.;Bittolo-Bon, G.;Bucci, A.;Buzzelli, G. B.;DePretis, G.;Dobrilla, G.;Dormi, A.;Farinaro, E.;Ferrario, M.;Gaddi, A.;Giacchi, M.;Giampaoli, S.;Mancini, M.;Marenco, G.;Misciagna, G.;Muntoni, Se;Muntoni, Sa;Ockoliczanyi, L.;Palasciano, G.;Ricci, G.;Salvioli, G. F.;Spagnolo, A.;Tenconi, M. T.;Urbinati, G. C.;Vanuzzo, D.;null, null

2024-01-01

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Abstract

Background: The impact of marital status on cardiovascular disease (CVD) remains controversial in the general population.AimThe present investigation sought to delineate the association between marital status and long-term major non-fatal and fatal CVD, along with all-cause mortality within the scope of the RIFLE project (Risk Factors and Life Expectancy).MethodsWe examined the incidences of CVD, including cerebrovascular accidents and coronary heart disease (CHD), as well as all-cause mortality. In total, 47,167 individuals (46% female, average age 50 +/- 9 years) were included in the analysis. Marital status at inception was categorized into married (inclusive of married or cohabitating) versus unmarried cohorts (including widowed, separated, divorced, or single individuals). Results Compared to their married counterparts, unmarried subjects demonstrated a heightened risk for CVD in both females and males. Throughout a median follow-up span of 7.4 years (interquartile range from 6 to 9 years), married participants, adjusting for standard risk factors, exhibited reduced mortality rates attributed to CHD [hazard ratio (HR) 0.54 (95% confidence interval (CI) 0.33-0.86)) and all causes (HR 0.75 (95% CI 0.62-0.91)] within the aggregate population; this reduction persisted for both CHD-specific [HR 0.39 (95% CI 0.51-0.90)]and all-cause mortality [HR 0.68 (95% CI 0.51-0.90)], independent of traditional risk factors in women. No associations were evident between matrimonial status and any measured outcomes in males.ConclusionsWithin primary care settings, marital status should be considered a potential correlate of long-term CHD and overall mortality risks, especially among women.