Synthesis and Biological Evaluation of a Novel Series of Bis-Salicylaldehydes as Mushroom Tyrosinase Inhibitors

DELOGU, GIOVANNA LUCIA;PODDA G;CORDA M;FADDA MB;FAIS, ANTONELLA;ERA, BENEDETTA

2010-01-01

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Abstract

A series of novel bis-salicylaldehydes were synthesised and evaluated as tyrosinase inhibitors using a tyrosinase-dependent L-DOPA oxidation assay. The bis-salicylaldehydes exhibited greater inhibitory activity than salicylaldehyde. Our data suggests that these novel compounds may serve as a structural template for the design and development of novel tyrosinase inhibitors.