Università degli Studi di Cagliari
ANGELA CORONA
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex
2024-01-01 Kuzikov, Maria; Reinshagen, Jeanette; Wycisk, Krzysztof; Corona, Angela; Esposito, Francesca; Malune, Paolo; Manelfi, Candida; Iaconis, Daniela; Beccari, Andrea; Tramontano, Enzo; Nowotny, Marcin; Windshügel, Bjorn; Gribbon, Philip; Zaliani, Andrea
New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors
2024-01-01 Messore, Antonella; Malune, Paolo; Patacchini, Elisa; Noemi Madia, Valentina; Ialongo, Davide; Arpacioglu, Merve; Albano, Aurora; Ruggieri, Giuseppe; Saccoliti, Francesco; Scipione, Luigi; Tramontano, Enzo; Canton, Serena; Corona, Angela; Scognamiglio, Sante; Paulis, Annalaura; Suleiman, Mustapha; Mohammed Al-Maqtari, Helmi; Abid, Fatma Mohamed A.; Kawsar, Sarkar M. A.; Sankaranarayanan, Murugesan; Di Santo, Roberto; Esposito, Francesca; Roberta Costi, And
Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity
2024-01-01 Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E.
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors
2024-01-01 Zhao, K. -X.; Zhang, Y. -Y.; Wang, J. -S.; Wang, S.; Corona, A.; Maloccu, S.; Tramontano, E.; Pannecouque, C.; De Clercq, E.; Meng, G.; Wang, L.; Chen, F. -E.
Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy
2024-01-01 Zhu, X. -D.; Corona, A.; Maloccu, S.; Tramontano, E.; Wang, S.; Pannecouque, C.; De Clercq, E.; Meng, G.; Chen, F. -E.
Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds
2023-01-01 Al Nasr, Ibrahim S; Corona, Angela; Koko, Waleed S; Khan, Tariq A; Ben Said, Ridha; Daoud, Ismail; Rahali, Seyfeddine; Tramontano, Enzo; Schobert, Rainer; Amdouni, Noureddine; Biersack, Bernhard
Naïve antibody library derived monoclonal antibody against VP35 of Ebola virus
2023-01-01 Lai, Jing Yi; Corona, Angela; Ng, Chong Lee; Tramontano, Enzo; Choong, Yee Siew; Lim, Theam Soon
Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action
2023-01-01 Corona, Angela; Strayer, David; Distinto, Simona; Daino, Gian Luca; Paulis, Annalaura; Tramontano, Enzo; Mitchell, William M
Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
2023-01-01 Porcu, Stefania; Maloccu, Stefania; Corona, Angela; Hazra, Moulika; David, TULLIA CARLA; Chiriu, Daniele; Carbonaro, CARLO MARIA; Tramontano, Enzo; Ricci, PIER CARLO
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
2023-01-01 Boniardi, Irene; Corona, Angela; Basquin, Jerome; Basquin, Claire; Milia, Jessica; Nagy, István; Tramontano, Enzo; Zinzula, Luca
Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication
2023-01-01 Asthana, A.; Corona, A.; Shin, W. -J.; Kwak, M. -J.; Gaughan, C.; Tramontano, E.; Jung, J. U.; Schobert, R.; Jha, B. K.; Silverman, R. H.; Biersack, B.
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
2023-01-01 Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E.
Editorial: Viruses, innate immunity, and antiviral strategies: from basic research to clinical applications
2023-01-01 Fanunza, Elisa; Corona, Angela
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication
2023-01-01 Corona, Angela; Madia, Valentina Noemi; De Santis, Riccardo; Manelfi, Candida; Emmolo, Roberta; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Amatore, Donatella; Faggioni, Giovanni; Artico, Marco; Iaconis, Daniela; Talarico, Carmine; Di Santo, Roberto; Lista, Florigio; Costi, Roberta; Tramontano, Enzo
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
2023-01-01 Stefanelli, Irina; Corona, Angela; Cerchia, Carmen; Cassese, Emilia; Improta, Salvatore; Costanzi, Elisa; Pelliccia, Sveva; Morasso, Stefano; Esposito, Francesca; Paulis, Annalaura; Scognamiglio, Sante; Di Leva, Francesco Saverio; Storici, Paola; Brindisi, Margherita; Tramontano, Enzo; Cannalire, Rolando; Summa, Vincenzo
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach
2023-01-01 Alessandra Ambrosio, Francesca; Costa, Giosuè; Romeo, Isabella; Esposito, Francesca; Alkhatib, Mohammad; Salpini, Romina; Svicher, Valentina; Corona, Angela; Malune, Paolo; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Alcaro, Stefano; Anna Artese, And
HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France)
2023-01-01 Sanna, Cinzia; D’Abrosca, Brigida; Fiorentino, Antonio; Giammarino, Federica; Vicenti, Ilaria; Corona, Angela; Caredda, Alessia; Tramontano, Enzo; Esposito, Francesca
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action
2023-01-01 Iaconis, Daniela; Caccuri, Francesca; Manelfi, Candida; Talarico, Carmine; Bugatti, Antonella; Filippini, Federica; Zani, Alberto; Novelli, Rubina; Kuzikov, Maria; Ellinger, Bernhard; Gribbon, Philip; Riecken, Kristoffer; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Beccari, Andrea Rosario; Caruso, Arnaldo; Allegretti, Marcello
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort
2022-01-01 Zaliani, Andrea; Vangeel, Laura; Reinshagen, Jeanette; Iaconis, Daniela; Kuzikov, Maria; Keminer, Oliver; Wolf, Markus; Ellinger, Bernhard; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Manelfi, Candida; Herzog, Katja; Jochmans, Dirk; De Jonghe, Steven; Chiu, Winston; Francken, Thibault; Schepers, Joost; Collard, Caroline; Abbasi, Kayvan; Claussen, Carsten; Summa, Vincenzo; Beccari, Andrea R.; Neyts, Johan; Gribbon, Philip; Leyssen, Pieter
Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach
2022-01-01 Romeo, Isabella; Ambrosio, Francesca Alessandra; Costa, Giosuè; Corona, Angela; Alkhatib, Mohammad; Salpini, Romina; Lemme, Saverio; Vergni, Davide; Svicher, Valentina; Santoro, Maria Mercedes; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Artese, Anna; Alcaro, Stefano
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity
2022-01-01 Nizi, Maria Giulia; Persoons, Leentje; Corona, Angela; Felicetti, Tommaso; Cernicchi, Giada; Massari, Serena; Manfroni, Giuseppe; Vangeel, Laura; Barreca, Maria Letizia; Esposito, Francesca; Jochmans, Dirk; Milia, Jessica; Cecchetti, Violetta; Schols, Dominique; Neyts, Johan; Tramontano, Enzo; Sabatini, Stefano; De Jonghe, Steven; Tabarrini, Oriana
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration
2022-01-01 Richetta, Clémence; Subra, Frédéric; Malet, Isabelle; Leh, Hervé; Charpentier, Charlotte; Corona, Angela; Collin, Gilles; Descamps, Diane; Deprez, Eric; Parissi, Vincent; Calvez, Vincent; Tramontano, Enzo; Marcelin, Anne-Geneviève; Delelis, Olivier
Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production
2022-01-01 Corona, Angela; Fanunza, Elisa; Salata, Cristiano; Morwitzer, Melody Jane; Distinto, Simona; Zinzula, Luca; Sanna, Cinzia; Frau, Aldo; Daino, Gian Luca; Quartu, Marina; Taglialatela-Scafati, Orazio; Rigano, Daniela; Reid, Stpatrick; Mirazimi, Alì; Tramontano, Enzo
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route
2022-01-01 Pelliccia, Sveva; Cerchia, Carmen; Esposito, Francesca; Cannalire, Rolando; Corona, Angela; Costanzi, Elisa; Kuzikov, Maria; Gribbon, Philip; Zaliani, Andrea; Brindisi, Margherita; Storici, Paola; Tramontano, Enzo; Summa, Vincenzo
Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities
2022-01-01 Corona, Angela; Wycisk, Krzysztof; Talarico, Carmine; Manelfi, Candida; Milia, Jessica; Cannalire, Rolando; Esposito, Francesca; Gribbon, Philip; Zaliani, Andrea; Iaconis, Daniela; Beccari, Andrea R.; Summa, Vincenzo; Nowotny, Marcin; Tramontano, Enzo
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
2021-01-01 Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo
Inhibitors of Ebolavirus targeting innate immune evasion
2021-01-01 Paulis, A. L.; Corona, A.; Tramontano, E.
In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds
2021-01-01 Sanna, C.; Marengo, A.; Acquadro, S.; Caredda, A.; Lai, R.; Corona, A.; Tramontano, E.; Rubiolo, P.; Esposito, F.
The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry
2021-01-01 Kuo, Yu-Ting; Liu, Ching-Hsuan; Corona, Angela; Fanunza, Elisa; Tramontano, Enzo; Lin, Liang-Tzung
Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H
2021-01-01 Corona, Angela; Seibt, Sebastian; Schaller, David; Schobert, Rainer; Volkamer, Andrea; Biersack, Bernhard; Tramontano, Enzo
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen
2021-01-01 Kuzikov, Maria; Costanzi, Elisa; Reinshagen, Jeanette; Esposito, Francesca; Vangeel, Laura; Wolf, Markus; Ellinger, Bernhard; Claussen, Carsten; Geisslinger, Gerd; Corona, Angela; Iaconis, Daniela; Talarico, Carmine; Manelfi, Candida; Cannalire, Rolando; Rossetti, Giulia; Gossen, Jonas; Albani, Simone; Musiani, Francesco; Herzog, Katja; Ye, Yang; Giabbai, Barbara; Demitri, Nicola; Jochmans, Dirk; De Jonghe, Steven; Rymenants, Jasper; Summa, Vincenzo; Tramontano, Enzo; Beccari, Andrea R.; Leyssen, Pieter; Storici, Paola; Neyts, Johan; Gribbon, Philip; Zaliani, Andrea
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase
2021-01-01 Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria; De Leo, Alessandro; Ialongo, Davide; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto
INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation
2021-01-01 Fanunza, Elisa; Grandi, Nicole; Quartu, Marina; Carletti, Fabrizio; Ermellino, Laura; Milia, Jessica; Corona, Angela; Rosaria Capobianchi, Maria; Ippolito, Giuseppe; Tramontano, Enzo
Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata
2021-01-01 Guzzo, Francesca; Russo, Rosita; Sanna, Cinzia; Celaj, Odeta; Caredda, Alessia; Corona, Angela; Tramontano, Enzo; Fiorentino, Antonio; Esposito, Francesca; D’Abrosca, Brigida
Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2
2021-01-01 Fanunza, Elisa; Carletti, Fabrizio; Quartu, Marina; Grandi, Nicole; Ermellino, Laura; Milia, Jessica; Corona, Angela; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Tramontano, Enzo
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions
2021-01-01 Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias
Natural and Nature-Derived Products Targeting Human Coronaviruses
2021-01-01 Vougogiannopoulou, Konstantina; Corona, Angela; Tramontano, Enzo; Alexis, Michael N.; Skaltsounis, Alexios-Leandros
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors
2020-01-01 Esposito, Francesca; Sechi, Mario; Pala, Nicolino; Sanna, Adele; Koneru, Pratibha Chowdary; Kvaratskhelia, Mamuka; Naesens, Lieve; Corona, Angela; Grandi, Nicole; di Santo, Roberto; D'Amore, Vincenzo Maria; Di Leva, Francesco Saverio; Novellino, Ettore; Cosconati, Sandro; Tramontano, Enzo
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
2020-01-01 Desantis, Jenny; Massari, Serena; Corona, Angela; Astolfi, Andrea; Sabatini, Stefano; Manfroni, Giuseppe; Palazzotti, Deborah; Cecchetti, Violetta; Pannecouque, Christophe; Tramontano, Enzo; Tabarrini, Oriana
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication
2020-01-01 Corona, Angela; Onnis, Valentina; Del Vecchio, Claudia; Esposito, Francesca; Cheng, Yung-Chi; Tramontano, Enzo
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants
2020-01-01 Corona, Angela; Ballana, Ester; Distinto, Simona; Rogolino, Dominga; Del Vecchio, Claudia; Carcelli, Mauro; Badia, Roger; Riveira-Muñoz, Eva; Esposito, Francesca; Parolin, Cristina; Esté, José A; Grandi, Nicole; Tramontano, Enzo
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase
2020-01-01 Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria; De Leo, Alessandro; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Di Maro, Salvatore; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Valenti, Piera; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto
Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H
2020-01-01 Tocco, Graziella; Esposito, Francesca; Caboni, Pierluigi; Laus, Antonio; Beutler, John A.; Wilson, Jennifer A.; Corona, Angela; Le Grice, Stuart F. J.; Tramontano, Enzo
Peptides Mimicking the β7/β8 loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors
2020-01-01 Sánchez-Murcia, Pedro A.; de Castro, Sonia; García-Aparicio, Carlos; Jimenez, M. Angeles; Corona, Angela; Tramontano, Enzo; Sluis-Cremer, Nicolas; Menendez Arias, Luis; Velazquez, Sonsoles; Gago, Federico; Camarasa, María-José
Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function
2020-01-01 Fanunza, Elisa; Iampietro, Mathieu; Distinto, Simona; Corona, Angela; Quartu, Marina; Maccioni, Elias; Horvat, Branka; Tramontano, Enzo
Relevance of Ebola virus VP35 homo-dimerization on the type I interferon cascade inhibition
2019-01-01 Di Palma, Francesco; Daino, Gian Luca; Ramaswamy, Venkata Krishnan; Corona, Angela; Frau, Aldo; Fanunza, Elisa; Vargiu, Attilio V; Tramontano, Enzo; Ruggerone, Paolo
Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus
2019-01-01 Tramontano, Enzo; Corona, Angela; Menendez-Arias, Luis
Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets
2019-01-01 Fanunza, Elisa; Frau, Aldo; Corona, Angela; Tramontano, Enzo
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques
2019-01-01 Costa, Giosuè; Rocca, Roberta; Corona, Angela; Grandi, Nicole; Moraca, Federica; Romeo, Isabella; Talarico, Carmine; Giovanna Gagliardi, Maria; Alessandra Ambrosio, Francesca; Ortuso, Francesco; Alcaro, Stefano; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo; Artese, Anna
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)
2019-01-01 Sanna, Cinzia; Rigano, Daniela; Corona, Angela; Piano, Dario; Formisano, Carmen; Farci, Domenica; Franzini, Genni; Ballero, Mauro; Chianese, Giuseppina; Tramontano, Enzo; Taglialatela-Scafati, Orazio; Esposito, Francesca
| Titolo | Data di pubblicazione | Autore(i) | Rivista | Editore |
|---|---|---|---|---|
| Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex | 1-gen-2024 | Kuzikov, Maria; Reinshagen, Jeanette; Wycisk, Krzysztof; Corona, Angela; Esposito, Francesca; Malune, Paolo; Manelfi, Candida; Iaconis, Daniela; Beccari, Andrea; Tramontano, Enzo; Nowotny, Marcin; Windshügel, Bjorn; Gribbon, Philip; Zaliani, Andrea | VIRUS RESEARCH | - |
| New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors | 1-gen-2024 | Messore, Antonella; Malune, Paolo; Patacchini, Elisa; Noemi Madia, Valentina; Ialongo, Davide; Arpacioglu, Merve; Albano, Aurora; Ruggieri, Giuseppe; Saccoliti, Francesco; Scipione, Luigi; Tramontano, Enzo; Canton, Serena; Corona, Angela; Scognamiglio, Sante; Paulis, Annalaura; Suleiman, Mustapha; Mohammed Al-Maqtari, Helmi; Abid, Fatma Mohamed A.; Kawsar, Sarkar M. A.; Sankaranarayanan, Murugesan; Di Santo, Roberto; Esposito, Francesca; Roberta Costi, And | PHARMACEUTICALS | - |
| Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity | 1-gen-2024 | Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E. | VIRUS RESEARCH | - |
| Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors | 1-gen-2024 | Zhao, K. -X.; Zhang, Y. -Y.; Wang, J. -S.; Wang, S.; Corona, A.; Maloccu, S.; Tramontano, E.; Pannecouque, C.; De Clercq, E.; Meng, G.; Wang, L.; Chen, F. -E. | BIOORGANIC CHEMISTRY | - |
| Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy | 1-gen-2024 | Zhu, X. -D.; Corona, A.; Maloccu, S.; Tramontano, E.; Wang, S.; Pannecouque, C.; De Clercq, E.; Meng, G.; Chen, F. -E. | MOLECULES | - |
| Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds | 1-gen-2023 | Al Nasr, Ibrahim S; Corona, Angela; Koko, Waleed S; Khan, Tariq A; Ben Said, Ridha; Daoud, Ismail; Rahali, Seyfeddine; Tramontano, Enzo; Schobert, Rainer; Amdouni, Noureddine; Biersack, Bernhard | BIOORGANIC & MEDICINAL CHEMISTRY | - |
| Naïve antibody library derived monoclonal antibody against VP35 of Ebola virus | 1-gen-2023 | Lai, Jing Yi; Corona, Angela; Ng, Chong Lee; Tramontano, Enzo; Choong, Yee Siew; Lim, Theam Soon | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
| Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action | 1-gen-2023 | Corona, Angela; Strayer, David; Distinto, Simona; Daino, Gian Luca; Paulis, Annalaura; Tramontano, Enzo; Mitchell, William M | ANTIVIRAL RESEARCH | - |
| Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst | 1-gen-2023 | Porcu, Stefania; Maloccu, Stefania; Corona, Angela; Hazra, Moulika; David, TULLIA CARLA; Chiriu, Daniele; Carbonaro, CARLO MARIA; Tramontano, Enzo; Ricci, PIER CARLO | POLYMERS | - |
| Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function | 1-gen-2023 | Boniardi, Irene; Corona, Angela; Basquin, Jerome; Basquin, Claire; Milia, Jessica; Nagy, István; Tramontano, Enzo; Zinzula, Luca | VIRUS RESEARCH | - |
| Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication | 1-gen-2023 | Asthana, A.; Corona, A.; Shin, W. -J.; Kwak, M. -J.; Gaughan, C.; Tramontano, E.; Jung, J. U.; Schobert, R.; Jha, B. K.; Silverman, R. H.; Biersack, B. | VIRUSES | - |
| 5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action | 1-gen-2023 | Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
| Editorial: Viruses, innate immunity, and antiviral strategies: from basic research to clinical applications | 1-gen-2023 | Fanunza, Elisa; Corona, Angela | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
| Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication | 1-gen-2023 | Corona, Angela; Madia, Valentina Noemi; De Santis, Riccardo; Manelfi, Candida; Emmolo, Roberta; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Amatore, Donatella; Faggioni, Giovanni; Artico, Marco; Iaconis, Daniela; Talarico, Carmine; Di Santo, Roberto; Lista, Florigio; Costi, Roberta; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination | 1-gen-2023 | Stefanelli, Irina; Corona, Angela; Cerchia, Carmen; Cassese, Emilia; Improta, Salvatore; Costanzi, Elisa; Pelliccia, Sveva; Morasso, Stefano; Esposito, Francesca; Paulis, Annalaura; Scognamiglio, Sante; Di Leva, Francesco Saverio; Storici, Paola; Brindisi, Margherita; Tramontano, Enzo; Cannalire, Rolando; Summa, Vincenzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach | 1-gen-2023 | Alessandra Ambrosio, Francesca; Costa, Giosuè; Romeo, Isabella; Esposito, Francesca; Alkhatib, Mohammad; Salpini, Romina; Svicher, Valentina; Corona, Angela; Malune, Paolo; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Alcaro, Stefano; Anna Artese, And | JOURNAL OF CHEMICAL INFORMATION AND MODELING | - |
| HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France) | 1-gen-2023 | Sanna, Cinzia; D’Abrosca, Brigida; Fiorentino, Antonio; Giammarino, Federica; Vicenti, Ilaria; Corona, Angela; Caredda, Alessia; Tramontano, Enzo; Esposito, Francesca | PHARMACEUTICALS | - |
| DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action | 1-gen-2023 | Iaconis, Daniela; Caccuri, Francesca; Manelfi, Candida; Talarico, Carmine; Bugatti, Antonella; Filippini, Federica; Zani, Alberto; Novelli, Rubina; Kuzikov, Maria; Ellinger, Bernhard; Gribbon, Philip; Riecken, Kristoffer; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Beccari, Andrea Rosario; Caruso, Arnaldo; Allegretti, Marcello | VIRUSES | - |
| Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort | 1-gen-2022 | Zaliani, Andrea; Vangeel, Laura; Reinshagen, Jeanette; Iaconis, Daniela; Kuzikov, Maria; Keminer, Oliver; Wolf, Markus; Ellinger, Bernhard; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Manelfi, Candida; Herzog, Katja; Jochmans, Dirk; De Jonghe, Steven; Chiu, Winston; Francken, Thibault; Schepers, Joost; Collard, Caroline; Abbasi, Kayvan; Claussen, Carsten; Summa, Vincenzo; Beccari, Andrea R.; Neyts, Johan; Gribbon, Philip; Leyssen, Pieter | SCIENTIFIC DATA | - |
| Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach | 1-gen-2022 | Romeo, Isabella; Ambrosio, Francesca Alessandra; Costa, Giosuè; Corona, Angela; Alkhatib, Mohammad; Salpini, Romina; Lemme, Saverio; Vergni, Davide; Svicher, Valentina; Santoro, Maria Mercedes; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Artese, Anna; Alcaro, Stefano | MOLECULES | - |
| Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity | 1-gen-2022 | Nizi, Maria Giulia; Persoons, Leentje; Corona, Angela; Felicetti, Tommaso; Cernicchi, Giada; Massari, Serena; Manfroni, Giuseppe; Vangeel, Laura; Barreca, Maria Letizia; Esposito, Francesca; Jochmans, Dirk; Milia, Jessica; Cecchetti, Violetta; Schols, Dominique; Neyts, Johan; Tramontano, Enzo; Sabatini, Stefano; De Jonghe, Steven; Tabarrini, Oriana | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration | 1-gen-2022 | Richetta, Clémence; Subra, Frédéric; Malet, Isabelle; Leh, Hervé; Charpentier, Charlotte; Corona, Angela; Collin, Gilles; Descamps, Diane; Deprez, Eric; Parissi, Vincent; Calvez, Vincent; Tramontano, Enzo; Marcelin, Anne-Geneviève; Delelis, Olivier | JOURNAL OF VIROLOGY | - |
| Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production | 1-gen-2022 | Corona, Angela; Fanunza, Elisa; Salata, Cristiano; Morwitzer, Melody Jane; Distinto, Simona; Zinzula, Luca; Sanna, Cinzia; Frau, Aldo; Daino, Gian Luca; Quartu, Marina; Taglialatela-Scafati, Orazio; Rigano, Daniela; Reid, Stpatrick; Mirazimi, Alì; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route | 1-gen-2022 | Pelliccia, Sveva; Cerchia, Carmen; Esposito, Francesca; Cannalire, Rolando; Corona, Angela; Costanzi, Elisa; Kuzikov, Maria; Gribbon, Philip; Zaliani, Andrea; Brindisi, Margherita; Storici, Paola; Tramontano, Enzo; Summa, Vincenzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities | 1-gen-2022 | Corona, Angela; Wycisk, Krzysztof; Talarico, Carmine; Manelfi, Candida; Milia, Jessica; Cannalire, Rolando; Esposito, Francesca; Gribbon, Philip; Zaliani, Andrea; Iaconis, Daniela; Beccari, Andrea R.; Summa, Vincenzo; Nowotny, Marcin; Tramontano, Enzo | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | - |
| Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function | 1-gen-2021 | Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Inhibitors of Ebolavirus targeting innate immune evasion | 1-gen-2021 | Paulis, A. L.; Corona, A.; Tramontano, E. | ANNUAL REPORTS IN MEDICINAL CHEMISTRY | - |
| In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds | 1-gen-2021 | Sanna, C.; Marengo, A.; Acquadro, S.; Caredda, A.; Lai, R.; Corona, A.; Tramontano, E.; Rubiolo, P.; Esposito, F. | PLANTS | - |
| The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry | 1-gen-2021 | Kuo, Yu-Ting; Liu, Ching-Hsuan; Corona, Angela; Fanunza, Elisa; Tramontano, Enzo; Lin, Liang-Tzung | VIRUSES | - |
| Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H | 1-gen-2021 | Corona, Angela; Seibt, Sebastian; Schaller, David; Schobert, Rainer; Volkamer, Andrea; Biersack, Bernhard; Tramontano, Enzo | ARCHIV DER PHARMAZIE | - |
| Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen | 1-gen-2021 | Kuzikov, Maria; Costanzi, Elisa; Reinshagen, Jeanette; Esposito, Francesca; Vangeel, Laura; Wolf, Markus; Ellinger, Bernhard; Claussen, Carsten; Geisslinger, Gerd; Corona, Angela; Iaconis, Daniela; Talarico, Carmine; Manelfi, Candida; Cannalire, Rolando; Rossetti, Giulia; Gossen, Jonas; Albani, Simone; Musiani, Francesco; Herzog, Katja; Ye, Yang; Giabbai, Barbara; Demitri, Nicola; Jochmans, Dirk; De Jonghe, Steven; Rymenants, Jasper; Summa, Vincenzo; Tramontano, Enzo; Beccari, Andrea R.; Leyssen, Pieter; Storici, Paola; Neyts, Johan; Gribbon, Philip; Zaliani, Andrea | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | - |
| Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase | 1-gen-2021 | Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria; De Leo, Alessandro; Ialongo, Davide; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto | JOURNAL OF MEDICINAL CHEMISTRY | - |
| INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation | 1-gen-2021 | Fanunza, Elisa; Grandi, Nicole; Quartu, Marina; Carletti, Fabrizio; Ermellino, Laura; Milia, Jessica; Corona, Angela; Rosaria Capobianchi, Maria; Ippolito, Giuseppe; Tramontano, Enzo | VIRUSES | - |
| Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata | 1-gen-2021 | Guzzo, Francesca; Russo, Rosita; Sanna, Cinzia; Celaj, Odeta; Caredda, Alessia; Corona, Angela; Tramontano, Enzo; Fiorentino, Antonio; Esposito, Francesca; D’Abrosca, Brigida | MOLECULES | - |
| Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2 | 1-gen-2021 | Fanunza, Elisa; Carletti, Fabrizio; Quartu, Marina; Grandi, Nicole; Ermellino, Laura; Milia, Jessica; Corona, Angela; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Tramontano, Enzo | VIRULENCE | - |
| Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions | 1-gen-2021 | Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias | MOLECULES | - |
| Natural and Nature-Derived Products Targeting Human Coronaviruses | 1-gen-2021 | Vougogiannopoulou, Konstantina; Corona, Angela; Tramontano, Enzo; Alexis, Michael N.; Skaltsounis, Alexios-Leandros | MOLECULES | - |
| Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors | 1-gen-2020 | Esposito, Francesca; Sechi, Mario; Pala, Nicolino; Sanna, Adele; Koneru, Pratibha Chowdary; Kvaratskhelia, Mamuka; Naesens, Lieve; Corona, Angela; Grandi, Nicole; di Santo, Roberto; D'Amore, Vincenzo Maria; Di Leva, Francesco Saverio; Novellino, Ettore; Cosconati, Sandro; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| 1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity | 1-gen-2020 | Desantis, Jenny; Massari, Serena; Corona, Angela; Astolfi, Andrea; Sabatini, Stefano; Manfroni, Giuseppe; Palazzotti, Deborah; Cecchetti, Violetta; Pannecouque, Christophe; Tramontano, Enzo; Tabarrini, Oriana | MOLECULES | - |
| 2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication | 1-gen-2020 | Corona, Angela; Onnis, Valentina; Del Vecchio, Claudia; Esposito, Francesca; Cheng, Yung-Chi; Tramontano, Enzo | MOLECULES | - |
| Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants | 1-gen-2020 | Corona, Angela; Ballana, Ester; Distinto, Simona; Rogolino, Dominga; Del Vecchio, Claudia; Carcelli, Mauro; Badia, Roger; Riveira-Muñoz, Eva; Esposito, Francesca; Parolin, Cristina; Esté, José A; Grandi, Nicole; Tramontano, Enzo | VIRUSES | - |
| Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase | 1-gen-2020 | Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria; De Leo, Alessandro; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Di Maro, Salvatore; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Valenti, Piera; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H | 1-gen-2020 | Tocco, Graziella; Esposito, Francesca; Caboni, Pierluigi; Laus, Antonio; Beutler, John A.; Wilson, Jennifer A.; Corona, Angela; Le Grice, Stuart F. J.; Tramontano, Enzo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Peptides Mimicking the β7/β8 loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors | 1-gen-2020 | Sánchez-Murcia, Pedro A.; de Castro, Sonia; García-Aparicio, Carlos; Jimenez, M. Angeles; Corona, Angela; Tramontano, Enzo; Sluis-Cremer, Nicolas; Menendez Arias, Luis; Velazquez, Sonsoles; Gago, Federico; Camarasa, María-José | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function | 1-gen-2020 | Fanunza, Elisa; Iampietro, Mathieu; Distinto, Simona; Corona, Angela; Quartu, Marina; Maccioni, Elias; Horvat, Branka; Tramontano, Enzo | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
| Relevance of Ebola virus VP35 homo-dimerization on the type I interferon cascade inhibition | 1-gen-2019 | Di Palma, Francesco; Daino, Gian Luca; Ramaswamy, Venkata Krishnan; Corona, Angela; Frau, Aldo; Fanunza, Elisa; Vargiu, Attilio V; Tramontano, Enzo; Ruggerone, Paolo | ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | - |
| Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus | 1-gen-2019 | Tramontano, Enzo; Corona, Angela; Menendez-Arias, Luis | ANTIVIRAL RESEARCH | - |
| Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets | 1-gen-2019 | Fanunza, Elisa; Frau, Aldo; Corona, Angela; Tramontano, Enzo | INFECTIOUS DISORDERS - DRUG TARGETS | - |
| Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques | 1-gen-2019 | Costa, Giosuè; Rocca, Roberta; Corona, Angela; Grandi, Nicole; Moraca, Federica; Romeo, Isabella; Talarico, Carmine; Giovanna Gagliardi, Maria; Alessandra Ambrosio, Francesca; Ortuso, Francesco; Alcaro, Stefano; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo; Artese, Anna | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy) | 1-gen-2019 | Sanna, Cinzia; Rigano, Daniela; Corona, Angela; Piano, Dario; Formisano, Carmen; Farci, Domenica; Franzini, Genni; Ballero, Mauro; Chianese, Giuseppina; Tramontano, Enzo; Taglialatela-Scafati, Orazio; Esposito, Francesca | NATURAL PRODUCT RESEARCH | - |
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