Università degli Studi di Cagliari
Characterization of the effects of a series of Aryl Substituted Imidazoles, as a novel class of potent and efficacious allosteric modulators of GABAA Receptor function
2003-01-01 Busonero, F.; Talani, G.; Tranquilli, S; Mascia, MARIA PIA; Mostallino, M. C.; Maciocco, E.; Asproni, B.; Cerri, R.; Sanna, E.
Alterazioni funzionali e molecolari dei recettori GABAA in cellule ippocampali di ratto dopo trattamento cronico e astinenza da etanolo
2002-01-01 Talani, G; Busonero, F; Mostallino M., C; Mameli, M; Carta, A; Vincis, C; Cadeddu, G; Tranquilli, Stefania; Follesa, Paolo; Sanna, E.
Aryl Substituted Imidazoles as a Novel Class of potent and Efficacious Allosteric Modulators of GABAA Receptor function
2002-01-01 Sanna, E.; Talani, G.; Busonero, F.; Tranquilli, Stefania; Mascia, M. P.; Maciocco, E.; Asproni, B.; Cerri, R.; Pau, A.; Biggio, G.
L’esposizione cronica delle cellule ippocampali di ratto alle benzodiazepine produce alterazioni nella funzione dei recettori GABAA
2002-01-01 Busonero, F; Talani, G; Mostallino M., C; Mameli, M; Carta, A; Vincis, C; Cadeddu, G; Tranquilli, Stefania; Follesa, Paolo; Sanna, E.
Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes
2002-01-01 Sanna, Enrico; Busonero, Fabio; Talani, Giuseppe; Carta, M; Massa, F; Peis, M; Maciocco, E; Biggio, G.
Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4 phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors
2002-01-01 Asproni, B; Pau, A; Bitti, M; Melosu, M; Cerri, R; Dazzi, Laura; Seu, E; Maciocco, E; Sanna, Enrico; Busonero, Fabio; Talani, Giuseppe; Pusceddu, L; Altomare, C; Trapani, G; Biggio, G.
GABA-A receptor lasticity during long-term exposure to and wuthdrawal from progesterone
2001-01-01 Biggio, G; Follesa, Paolo; Sanna, E; Purdy, Rh; Concas, Alessandra
Role of allopregnanolone in regulation of GABA(A) receptor plasticity during long-term exposure to and withdrawal from progesterone
2001-01-01 Follesa, P; Concas, A; Porcu, P; Sanna, E; Serra, M; Mostallino, Mc; Purdy, Rh; Biggio, G
Increase in expression of the GABA(A) receptor alpha(4) subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists
2001-01-01 Follesa, Paolo; Cagetti, E; Mancuso, Luisa; Biggio, Francesca; Manca, Annalisa; Maciocco, E; Massa, F; Desole, Ms; Carta, M; Busonero, Fabio; Sanna, E; Biggio, G.
PROPOFOL IN ANESTHESIA: MECHANISM OF ACTION, STRUCTURE-ACTIVITY RELATIONSHIPS, AND DRUG DELIVERY
2000-01-01 Trapani, G.; Altomare, C.; Sanna, Enrico; Biggio, G.; Liso, G.
Allopregnanolone synthesis in cerebellar granule cells: roles in regulation of GABA(A) receptor expression and function during progesterone treatment and withdrawal
2000-01-01 Follesa, Paolo; Serra, Mariangela; Cagetti, E; Giuseppina, M; Pisu, Mg; Porta, S; Floris, S; Massa, F; Sanna, E; Biggio, G.
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
2000-01-01 Serra, Mariangela; Pisu, Mg; Littera, M; Papi, G; Sanna, E; Tuveri, F; Usala, L; Purdy, Rh; Biggio, G.
Novel 2-phebylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding, and in vivo studies
1999-01-01 Trapani, G; Franco, M; Latrofa, A; Ricciardi, L; Carotti, A; Serra, M; Sanna, Enrico; Biggio, G; AND LISO, G.
2-phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats
1999-01-01 Serra, Mariangela; Madau, P; Chessa, Mf; Caddeo, M; Sanna, Enrico; Trapani, G; Franco, M; Liso, G; Purdy, Rh; Barbaccia, Ml; Biggio, G.
MOLECULAR AND NEUROCHEMICAL EVALUATION OF THE EFFECTS OF ETIZOLAM ON GABAA RECEPTORS UNDER NORMAL AND STRESS CONDITIONS
1999-01-01 Sanna, Enrico; Pau, D.; Tuveri, F.; Massa, F.; Maciocco, E.; Acquas, C.; Floris, C.; Fontana, S. N.; Maira, G.; Biggio, G.
Increased abundance of GABAA receptor subunit mRNAs in the brain of Long-Evans Cinnamon rats, an animal model of Wilson's disease
1999-01-01 Follesa, Paolo; Mallei, A; Floris, S; Mostallino, Mc; Sanna, E; Biggio, G.
Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: Synthesis, binding affinity, and in vivo studies
1999-01-01 Trapani, G; Franco, M; Latrofa, A; Ricciardi, L; Carotti, A; Serra, Mariangela; Sanna, E; Biggio, G; Liso, G.
Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties
1999-01-01 Sanna, Enrico; Motzo, Costantino; Usala, M; Serra, Mariangela; Dazzi, Laura; Maciocco, E; Trapani, G; Latrofa, A; Liso, G; Biggio, G.
Inclusion complexation of propofol with 2-hydroxypropyl-beta-cyclodextrin. Physicochemcial, nuclear magnetic resonance spectroscopic studies, and anesthetic properties in rat
1998-01-01 Trapani, G; Latrofa, A; Franco, M; Lapedota, A; Sanna, Enrico
Propofol analogues. Synthesis, relationships between structure and affinity at GABA-A receptors in rat brain, and differential electrophysiological profile at recombinant human GABA-A receptors
1998-01-01 Trapani, G; Latrofa, A; Franco, M; Altomare, C; Sanna, Enrico; Usala, M; Biggio, G; AND LISO, G.
Functional changes in rat nigral GABA(A) receptors induced by degeneration of the striatonigral GABAergic pathway: An electrophysiological study of receptors incorporated into Xenopus oocytes
1998-01-01 Sanna, Enrico; Motzo, Costantino; Usala, M; Pau, D; Cagetti, E; Biggio, G.
SYNTHESIS AND BINDING AFFINITY OF 2--PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES FOR BOTH CENTRAL AND PERIPHERAL BENZODIAZEPINE RECEPTORS. A NEW SERIES OF HIGH-AFFINITY AND SELECTIVE LIGANDS FOR THE PERIPHERAL TYPE
1997-01-01 Trapani, G.; Franco, M.; Ricciardi, L.; Latrofa, A.; Genchi, G.; Sanna, Enrico; Tuveri, F.; Cagetti, E.; Biggio, G.; Liso, G.
DIFFERENTIAL SUBUNIT DEPENDENCE OF THE ACTIONS OF THE GENERAL ANESTHETICS ALPHAXALONE AND ETOMIDATE AT GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTORS EXPRESSED IN XENOPUS LAEVIS OOCYTES
1997-01-01 Sanna, Enrico; Murgia, A.; Casula, A.; Biggio, G.
Modulation of 6-hydroxydopamine oxidation by various proteins
1997-01-01 Padiglia, Alessandra; Medda, Rosaria; Lorrai, A; Biggio, G; Sanna, E; Floris, G.
Expression of native GABAA receptors in Xenopus oocytes injected with rat brain synaptosomes
1996-01-01 Sanna, E; Motzo, Costantino; Murgia, A; Amato, F; Deserra, T; Biggio, G.
Biochemical evaluations of the effects of loreclezole and propofol on the GABA(A) receptor in rat brain
1996-01-01 Ghiani, Ca; Tuligi, G; Maciocco, E; Serra, Mariangela; Sanna, E; Biggio, G.
PROCONFLICT EFFECT OF CARBON-DIOXIDE INHALATION IN RATS
1995-01-01 Cuccheddu, T; Floris, S; Serra, Mariangela; Porceddu, Ml; Sanna, E; Biggio, G.
Carbon dioxide inhalation, stress and anxiogenic drugs reduce the function of GABAA receptor complex in the rat brain.
1993-01-01 Concas, Alessandra; Sanna, E.; Cuccheddu, T.; Mascia, M. P.; Santoro, G.; Maciocco, E.; Biggio, G.
Stress and GABAergic transmission in the rat brain: the effect of carbon dioxide inhalation
1993-01-01 Biggio, G.; Cuccheddu, T.; Floris, S.; Sanna, E.; Barbaccia, M. L.; Roscetti, G.; Serra, M.; Concas, Alessandra
GABAA-receptor complex: a target site for general anesthetics and ethanol.
1993-01-01 Concas, Alessandra; Sanna, E.; Serra, M.; Santoro, G.; Biggio, G.
Chronic ethanol intoxication induces differential effects on GABAA and NMDA receptor function in the rat brain
1993-01-01 Sanna, E; Serra, Mariangela; Cossu, A; Colombo, G; Follesa, Paolo; Cuccheddu, T; Concas, Alessandra; Biggio, G.
THE ACTION OF THE GENERAL ANESTHETIC PROPOFOL ON GABA(A) RECEPTORS
1992-01-01 Concas, Alessandra; Santoro, G; Mascia, Mp; Serra, Mariangela; Sanna, E; Biggio, G.
Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs.
1992-01-01 Concas, Alessandra; Serra, M; Sanna, E; Pepitoni, S; Mascia, Mp; Biggio, G.
Pharmacology of gamma-aminobutyric acid(A) receptor complex after the in vivo administration of the anxioselective and anticonvulsant beta-carboline derivative abecarnil
1992-01-01 Serra, Mariangela; Foddi M., C; Ghiani C., A; Melis M., A; Motzo, C; Concas, Alessandra; Sanna, E; Biggio, G.
GABAA and NMDA receptor function during chronic administration of ethanol
1992-01-01 Sanna, E; Serra, Mariangela; Cossu, A; Colombo, G; Follesa, Paolo; Biggio, G.
CARBON-DIOXIDE INHALATION REDUCES THE FUNCTION OF GABA-A RECEPTORS IN THE RAT-BRAIN
1992-01-01 Sanna, E.; Cuccheddu, T.; Serra, Mariangela; Concas, Alessandra; Biggio, G.
Ex vivo binding of t-[35S]butylbicyclophosphorothionate: a biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel
1991-01-01 Sanna, E; Concas, Alessandra; Serra, M; Santoro, G; Biggio, G.
Ex vivo binding of tert-[S-35]butylbicyclophosphorothionate - A biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel
1991-01-01 Sanna, E; Concas, Alessandra; Serra, Mariangela; Santoro, G; Biggio, G.
"In vivo" inhibition of GABAergic transmission increases 35S-TBPS binding in the rat brain.
1991-01-01 Biggio, G.; Sanna, E.; Serra, M.; Serra, G. P.; Concas, Alessandra
"In vivo" administration of valproate decreases t [35S]butylbicyclophosphorothionate binding in the rat brain.
1991-01-01 Concas, Alessandra; Mascia, M. P.; Sanna, E.; Santoro, G.; Serra, M.; Biggio, G.
In vivo administration of valproate decreases tert-[S-35]butylbicyclophosphorothionate binding in the rat brain
1991-01-01 Concas, Alessandra; Mascia M., P; Sanna, E; Santoro, G; Serra, Mariangela; Biggio, G.
Failure of gamma-hydroxybutyrate to alter the function of the GABAA receptor complex in the rat cerebral cortex
1991-01-01 Serra, Mariangela; Sanna, E; Foddi, C; Concas, Alessandra; Biggio, G.
Foot shock stress enhances the increase of [35S]TBPS binding in the rat cerebral cortex and the convulsions induced by isoniazid
1991-01-01 Serra, Mariangela; Sanna, E; Concas, Alessandra; Foddi, C; Biggio, G.
Enhancement of GABA-dependent chloride channel by "in vivo" administration of ethanol.
1990-01-01 Sanna, E; Concas, Alessandra; Serra, M; Biggio, G.
Diazepam enhances bicuculline-induced increase of t-[35S]butylbicyclophosphorothionate binding in unwashed membrane preparations from rat cerebral cortex.
1990-01-01 Concas, Alessandra; Sanna, E; Mascia, Mp; Serra, Mariangela; Biggio, G.
Biochemical evidence for an involvement of the GABA dependent chloride channel in the action of stress, anxiogenic and anxiolytic ligands for benzodiazepine receptors.
1990-01-01 Biggio, G.; Serra, M.; Sanna, E.; Concas, Alessandra
In vivo administration of ethanol enhances the function of the gamma-aminobutyric acid-dependent chloride channel in the rat cerebral cortex
1990-01-01 Sanna, E; Concas, Alessandra; Serra, Mariangela; Biggio, G.
The general anesthetic propofol enhances the function of γ aminobutyric acid coupled chloride channel in the rat cerebral cortex
1990-01-01 Concas, Alessandra; Santoro, G; Mascia, Mp; Serra, Mariangela; Sanna, E; Biggio, G.
The action of stress and anxiolytic and anxiogenic benzodiazepine receptors ligands on [35S] T-butylbicyclophosphorothionate binding in the rat cerebral cortex.
1990-01-01 Concas, Alessandra; Serra, Mariangela; Sanna, E; Biggio, G.
"Ex vivo" binding of 35S-TBPS as a tool to study the pharmacology of GABAA receptors.
1990-01-01 Concas, Alessandra; Sanna, E; Serra, Mariangela; Mascia M., P; Santoro, V; Biggio, G.
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