---

2021 HOT PCCP article: You can download for free our contribution:

https://pubs.rsc.org/en/content/articlepdf/2021/cp/d1cp02947a?page=search

We contributed to it by investigating a lysosomal ion channel, hTPC2, that is involved in virus entry. By inhibiting it in principle we can stop Sars-Cov-2 entry and thus the infection. However, this ion channel shows singular features not found in other ion channels, such as a different selectivity depending on the effector interacting with it. Within this paper we focused on sodium transport, highlighting several features of hTPC2 that could help in the aforementioned inhibition of the channel. Also, we suggest a transport mechanism that differs in certain aspects from the conventional view.