Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

Colafigli M.;Torti C.;Trecarichi E. M.;Albini L.;Rosi A.;Micheli V.;Manca N.;Penco G.;Bruzzone B.;Punzi G.;Corsi P.;Parruti G.;Bagnarelli P.;Monno L.;Gonnelli A.;Cauda R.;Di Giambenedetto S.;Mandas A

Member of the Collaboration Group

2012-01-01

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Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.