University of Cagliari
open
Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action
Corona, AngelaFirst
;Distinto, Simona;Daino, Gian Luca;Paulis, Annalaura;Tramontano, EnzoPenultimate
;
2023-01-01
Abstract
Ebola virus (EBOV) is a highly infectious and lethal pathogen responsible for sporadic self-limiting clusters of Ebola virus disease (EVD) in Central Africa capable of reaching epidemic status. 100% protection from lethal EBOV-Zaire in Balb/c mice was achieved by rintatolimod (Ampligen) at the well tolerated human clinical dose of 6 mg/kg. The data indicate that the mechanism of action is rintatolimod's dual ability to act as both a competitive decoy for the IID domain of VP35 blocking viral dsRNA sequestration and as a pathogen-associated molecular pattern (PAMP) restricted agonist for direct TLR3 activation but lacking RIG-1-like cytosolic helicase agonist properties. These data show promise for rintatolimod as a prophylactic therapy against human Ebola outbreaks.
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| 2023 Antiviral Research1-s2.0-S0166354223000323-main.pdf open access
Type: versione editoriale
Size 3.04 MB
Format Adobe PDF
|
3.04 MB | Adobe PDF | View/Open |
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