Morpholine- and Thiomorpholine-Based Amidodithiophosphonato Nickel Complexes: Synthesis, Characterization, P-N Cleavage, Antibacterial Activity and Silica Nano-Dispersion
Podda, EnricoMember of the Collaboration Group
;Carla Aragoni, M
Member of the Collaboration Group
;Arca, MassimilianoMember of the Collaboration Group
;Atzeni, GiuliaMember of the Collaboration Group
;Ennas, GuidoMember of the Collaboration Group
;Isaia, FrancescoMember of the Collaboration Group
;Lippolis, VitoMember of the Collaboration Group
;Orru, GermanoMember of the Collaboration Group
;Scano, AlessandraMember of the Collaboration Group
;Pintus, AnnaMember of the Collaboration Group
;Scano, AlessandraMember of the Collaboration Group
2021-01-01
Abstract
The reactivity of thiomorpholinium P-(4-methoxyphenyl)-N-thiomorpholin-amidodithiophosphonate (S-MorH+₂)(S-Mor-adtp-) and morpholinium P-(4-methoxyphenyl)-N-morpholin-amidodithiophosphonate (O-MorH+₂)(O-Mor-adtp-) towards nickel (II) dichloride hexahydrated is presented and the hydrolysis of the relevant metal complexes investigated. The hydrolytic products (S-MorH+₂)₂ [Ni(dtp)₂]²- and (O-MorH+₂)₂[Ni(dtp)₂]²- were characterized by means of FT-IR, 1H, and 31P NMR and XRD and the experimented P-N cleavage investigated and elucidated by means of DFT calculations. The antimicrobial activity of the neutral nickel complex [Ni(S-Mor-adtp)₂] was tested against a set of Gram-positive and Gram-negative bacteria alongside with its nanodispersion in a silica matrix. The complex [Ni(S-Mor-adtp)₂] did not show antibacterial activity, whilst the nano-dispersed sample [Ni(S-Mor-adtp)₂]_SiO₂ demonstrated inhibition to growth of Staphylococcus aureus. The nanocomposites were fully characterized by means of XRPD, TGA, SEM and dinitrogen sorption techniques.File | Size | Format | |
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21JNN-19058-Ennas_Thiomorpholine.pdf Solo gestori archivio
Type: Author’s Accepted Manuscript AAM, Post-print, (version accepted by the publisher)
Size 1.32 MB
Format Adobe PDF
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