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A Bronsted acid catalyzed tandem reaction for the diastereoselective synthesis of cyclobuta-fused tetrahydroquinoline carboxylic esters

Caboni, P;Secci, F;Frongia, A
2021-01-01

Abstract

A novel Bronsted acid catalyzed tandem reaction provides highly functionalized cyclobuta-fused tetrahydroquinoline carboxylic esters from anilines and 2-alkylenecyclobutanones in good to high yield. During the reaction a dynamic diastereoselective cyclization is achieved, resulting in the formation of three contiguous stereocenters with high stereoselectivity.
2021
2021
Inglese
ORGANIC & BIOMOLECULAR CHEMISTRY
19
41
8912
8916
5
WOS:000704011000001
2-s2.0-85118248831
34612296
https://pubs.rsc.org/en/content/articlelanding/2021/ob/d1ob01518d
Esperti anonimi
internazionale
scientifica
sì
Marras, V; Caboni, P; Secci, F; Guillot, R; Aitken, Dj; Frongia, A
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
partially_open
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