Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, Cristian;Teumer, Alexander;Gorski, Mathias;Chu, Audrey Y.;Li, Man;Mijatovic, Vladan;Garnaas, Maija;Tin, Adrienne;Sorice, Rossella;Li, Yong;Taliun, Daniel;Olden, Matthias;Foster, Meredith;Yang, Qiong;Chen, Ming-Huei;Pers, Tune H.;Johnson, Andrew D.;Ko, Yi-An;Fuchsberger, Christian;Tayo, Bamidele;Nalls, Michael;Feitosa, Mary F.;Isaacs, Aaron;Dehghan, Abbas;D'Adamo, Pio;Adeyemo, Adebowale;Dieffenbach, Aida Karina;Zonderman, Alan B.;Nolte, Ilja M.;Van Der Most, Peter J.;Wright, Alan F.;Shuldiner, Alan R.;Morrison, Alanna C.;Hofman, Albert;Smith, Albert V.;Dreisbach, Albert W.;Franke, Andre;Uitterlinden, Andre G.;Metspalu, Andres;Tonjes, Anke;Lupo, Antonio;Robino, Antonietta;Johansson, Åsa;Demirkan, Ayse;Kollerits, Barbara;Freedman, Barry I.;Ponte, Belen;Oostra, Ben A.;Paulweber, Bernhard;Krämer, Bernhard K.;Mitchell, Braxton D.;Buckley, Brendan M.;Peralta, Carmen A.;Hayward, Caroline;Helmer, Catherine;Rotimi, Charles N.;Shaffer, Christian M.;Müller, Christian;Sala, Cinzia;Van Duijn, Cornelia M.;Saint-Pierre, Aude;Ackermann, Daniel;Shriner, Daniel;Ruggiero, Daniela;Toniolo, Daniela;Lu, Yingchang;Cusi, Daniele;Czamara, Darina;Ellinghaus, David;Siscovick, David S.;Ruderfer, Douglas;Gieger, Christian;Grallert, Harald;Rochtchina, Elena;Atkinson, Elizabeth J.;Holliday, Elizabeth G.;Boerwinkle, Eric;Salvi, Erika;Bottinger, Erwin P.;Murgia, Federico;Rivadeneira, Fernando;Ernst, Florian;Kronenberg, Florian;Hu, Frank B.;Navis, Gerjan J.;Curhan, Gary C.;Ehret, George B.;Homuth, Georg;Coassin, Stefan;Thun, Gian-Andri;Pistis, Giorgio;Gambaro, Giovanni;Malerba, Giovanni;Montgomery, Grant W.;Eiriksdottir, Gudny;Jacobs, Gunnar;Li, Guo;Wichmann, H-Erich;Campbell, Harry;Schmidt, Helena;Wallaschofski, Henri;Völzke, Henry;Brenner, Hermann;Kroemer, Heyo K.;Kramer, Holly;Lin, Honghuang;Leach, I. Mateo;Ford, Ian;Guessous, Idris;Rudan, Igor;Prokopenko, Inga;Borecki, Ingrid;Heid, Iris M.;Kolcic, Ivana;Persico, Ivana;Jukema, J. Wouter;Wilson, James F.;Felix, Janine F.;Divers, Jasmin;Lambert, Jean-Charles;Stafford, Jeanette M.;Gaspoz, Jean-Michel;Smith, Jennifer A.;Faul, Jessica D.;Wang, Jie Jin;Ding, Jingzhong;Hirschhorn, Joel N.;Attia, John;Whitfield, John B.;Chalmers, John;Viikari, Jorma;Coresh, Josef;Denny, Joshua C.;Karjalainen, Juha;Fernandes, Jyotika K.;Endlich, Karlhans;Butterbach, Katja;Keene, Keith L.;Lohman, Kurt;Portas, Laura;Launer, Lenore J.;Lyytikäinen, Leo-Pekka;Yengo, Loic;Franke, Lude;Ferrucci, Luigi;Rose, Lynda M.;Kedenko, Lyudmyla;Rao, Madhumathi;Struchalin, Maksim;Kleber, Marcus E.;Cavalieri, Margherita;Haun, Margot;Cornelis, Marilyn C.;Ciullo, Marina;Pirastu, Mario;De Andrade, Mariza;McEvoy, Mark A.;Woodward, Mark;Adam, Martin;Cocca, Massimiliano;Nauck, Matthias;Imboden, Medea;Waldenberger, Melanie;Pruijm, Menno;Metzger, Marie;Stumvoll, Michael;Evans, Michele K.;Sale, Michele M.;Kähönen, Mika;Boban, Mladen;Bochud, Murielle;Rheinberger, Myriam;Verweij, Niek;Bouatia-Naji, Nabila;Martin, Nicholas G.;Hastie, Nick;Probst-Hensch, Nicole;Soranzo, Nicole;Devuyst, Olivier;Raitakari, Olli;Gottesman, Omri;Franco, Oscar H.;Polasek, Ozren;Gasparini, Paolo;Munroe, Patricia B.;Ridker, Paul M.;Mitchell, Paul;Muntner, Paul;Meisinger, Christa;Smit, Johannes H.;Abecasis, Goncalo R.;Adair, Linda S.;Alexander, Myriam;Altshuler, David;Amin, Najaf;Arking, Dan E.;Arora, Pankaj;Aulchenko, Yurii;Bakker, Stephan J. L.;Bandinelli, Stefania;Barroso, Ines;Beckmann, Jacques S.;Beilby, John P.;Bergman, Richard N.;Bergmann, Sven;Bis, Joshua C.;Boehnke, Michael;Bonnycastle, Lori L.;Bornstein, Stefan R.;Bots, Michiel L.;Bragg-Gresham, Jennifer L.;Brand, Stefan-Martin;Brand, Eva;Braund, Peter S.;Brown, Morris J.;Burton, Paul R.;Casas, Juan P.;Caulfield, Mark J.;Chakravarti, Aravinda;Chambers, John C.;Chandak, Giriraj R.;Chang, Yen-Pei C.;Charchar, Fadi J.;Chaturvedi, Nish;Cho, Yoon Shin;Clarke, Robert;Collins, Francis S.;Collins, Rory;Connell, John M.;Cooper, Jackie A.;Cooper, Matthew N.;Cooper, Richard S.;Corsi, Anna Maria;Dörr, Marcus;Dahgam, Santosh;Danesh, John;Smith, George Davey;Day, Ian N. M.;Deloukas, Panos;Denniff, Matthew;Dominiczak, Anna F.;Dong, Yanbin;Doumatey, Ayo;Elliott, Paul;Elosua, Roberto;Erdmann, Jeanette;Eyheramendy, Susana;Farrall, Martin;Fava, Cristiano;Forrester, Terrence;Fowkes, F. Gerald R.;Fox, Ervin R.;Frayling, Timothy M.;Galan, Pilar;Ganesh, Santhi K.;Garcia, Melissa;Gaunt, Tom R.;Glazer, Nicole L.;Go, Min Jin;Goel, Anuj;Grässler, Jürgen;Grobbee, Diederick E.;Groop, Leif;Guarrera, Simonetta;Guo, Xiuqing;Hadley, David;Hamsten, Anders;Han, Bok-Ghee;Hardy, Rebecca;Hartikainen, Anna-Liisa;Heath, Simon;Heckbert, Susan R.;Hedblad, Bo;Hercberg, Serge;Hernandez, Dena;Hicks, Andrew A.;Hilton, Gina;Hingorani, Aroon D.;Hoffman Bolton, Judith A.;Hopewell, Jemma C.;Howard, Philip;Humphries, Steve E.;Hunt, Steven C.;Hveem, Kristian;Ikram, M. Arfan;Islam, Muhammad;Iwai, Naoharu;Jarvelin, Marjo-Riitta;Jackson, Anne U.;Jafar, Tazeen H.;Janipalli, Charles S.;Johnson, Toby;Kathiresan, Sekar;Khaw, Kay-Tee;Kim, Hyung-Lae;Kinra, Sanjay;Kita, Yoshikuni;Kivimaki, Mika;Kooner, Jaspal S.;Kumar, M. J. Kranthi;Kuh, Diana;Kulkarni, Smita R.;Kumari, Meena;Kuusisto, Johanna;Kuznetsova, Tatiana;Laakso, Markku;Laan, Maris;Laitinen, Jaana;Lakatta, Edward G.;Langefeld, Carl D.;Larson, Martin G.;Lathrop, Mark;Lawlor, Debbie A.;Lawrence, Robert W.;Lee, Jong-Young;Lee, Nanette R.;Levy, Daniel;Li, Yali;Longstreth, Will T.;Luan, Jian'an;Lucas, Gavin;Ludwig, Barbara;Mangino, Massimo;Mani, K. Radha;Marmot, Michael G.;Mattace-Raso, Francesco U. S.;Matullo, Giuseppe;McArdle, Wendy L.;McKenzie, Colin A.;Meitinger, Thomas;Melander, Olle;Meneton, Pierre;Meschia, James F.;Miki, Tetsuro;Milaneschi, Yuri;Mohlke, Karen L.;Mooser, Vincent;Morken, Mario A.;Morris, Richard W.;Mosley, Thomas H.;Najjar, Samer;Narisu, Narisu;Newton-Cheh, Christopher;Nguyen, Khanh-Dung Hoang;Nilsson, Peter;Nyberg, Fredrik;O'Donnell, Christopher J.;Ogihara, Toshio;Ohkubo, Takayoshi;Okamura, Tomonori;Ong, Rick Twee-Hee;Ongen, Halit;Onland-Moret, N. Charlotte;O'Reilly, Paul F.;Org, Elin;Orru, Marco;Palmas, Walter;Palmen, Jutta;Palmer, Lyle J.;Palmer, Nicholette D.;Parker, Alex N.;Peden, John F.;Peltonen, Leena;Perola, Markus;Pihur, Vasyl;Platou, Carl G. P.;Plump, Andrew;Prabhakaran, Dorairajan;Psaty, Bruce M.;Raffel, Leslie J.;Rao, Dabeeru C.;Rasheed, Asif;Ricceri, Fulvio;Rice, Kenneth M.;Rosengren, Annika;Rotter, Jerome I.;Rudock, Megan E.;Sõber, Siim;Salako, Tunde;Saleheen, Danish;Salomaa, Veikko;Samani, Nilesh J.;Schwartz, Steven M.;Schwarz, Peter E. H.;Scott, Laura J.;Scott, James;Scuteri, Angelo;Sehmi, Joban S.;Seielstad, Mark;Seshadri, Sudha;Sharma, Pankaj;Shaw-Hawkins, Sue;Shi, Gang;Shrine, Nick R. G.;Sijbrands, Eric J. G.;Sim, Xueling;Singleton, Andrew;Sjögren, Marketa;Smith, Nicholas L.;Artigas, Maria Soler;Spector, Tim D.;Staessen, Jan A.;Stancakova, Alena;Steinle, Nanette I.;Strachan, David P.;Stringham, Heather M.;Sun, Yan V.;Swift, Amy J.;Tabara, Yasuharu;Tai, E-Shyong;Talmud, Philippa J.;Taylor, Andrew;Terzic, Janos;Thelle, Dag S.;Tobin, Martin D.;Tomaszewski, Maciej;Tripathy, Vikal;Tuomilehto, Jaakko;Tzoulaki, Ioanna;Uda, Manuela;Ueshima, Hirotsugu;Uiterwaal, Cuno S. P. M.;Umemura, Satoshi;Van Der Harst, Pim;Van Der Schouw, Yvonne T.;Van Gilst, Wiek H.;Vartiainen, Erkki;Vasan, Ramachandran S.;Veldre, Gudrun;Verwoert, Germaine C.;Viigimaa, Margus;Vinay, D. G.;Vineis, Paolo;Voight, Benjamin F.;Vollenweider, Peter;Wagenknecht, Lynne E.;Wain, Louise V.;Wang, Xiaoling;Wang, Thomas J.;Wareham, Nicholas J.;Watkins, Hugh;Weder, Alan B.;Whincup, Peter H.;Wiggins, Kerri L.;Witteman, Jacqueline C. M.;Wong, Andrew;Wu, Ying;Yajnik, Chittaranjan S.;Yao, Jie;Young, J. H.;Zelenika, Diana;Zhai, Guangju;Zhang, Weihua;Zhang, Feng;Zhao, Jing Hua;Zhu, Haidong;Zhu, Xiaofeng;Zitting, Paavo;Zukowska-Szczechowska, Ewa;Okada, Yukinori;Wu, Jer-Yuarn;Gu, Dongfeng;Takeuchi, Fumihiko;Takahashi, Atsushi;Maeda, Shiro;Tsunoda, Tatsuhiko;Chen, Peng;Lim, Su-Chi;Wong, Tien-Yin;Liu, Jianjun;Young, Terri L.;Aung, Tin;Teo, Yik-Ying;Kim, Young Jin;Kang, Daehee;Chen, Chien-Hsiun;Tsai, Fuu-Jen;Chang, Li-Ching;Fann, S. -J. Cathy;Mei, Hao;Hixson, James E.;Chen, Shufeng;Katsuya, Tomohiro;Isono, Masato;Albrecht, Eva;Yamamoto, Kazuhiko;Kubo, Michiaki;Nakamura, Yusuke;Kamatani, Naoyuki;Kato, Norihiro;He, Jiang;Chen, Yuan-Tsong;Tanaka, Toshihiro;Reilly, Muredach P.;Schunkert, Heribert;Assimes, Themistocles L.;Hall, Alistair;Hengstenberg, Christian;König, Inke R.;Laaksonen, Reijo;McPherson, Ruth;Thompson, John R.;Thorsteinsdottir, Unnur;Ziegler, Andreas;Absher, Devin;Chen, Li;Cupples, L. Adrienne;Halperin, Eran;Li, Mingyao;Musunuru, Kiran;Preuss, Michael;Schillert, Arne;Thorleifsson, Gudmar;Wells, George A.;Holm, Hilma;Roberts, Robert;Stewart, Alexandre F. R.;Fortmann, Stephen;Go, Alan;Hlatky, Mark;Iribarren, Carlos;Knowles, Joshua;Myers, Richard;Quertermous, Thomas;Sidney, Steven;Risch, Neil;Tang, Hua;Blankenberg, Stefan;Schnabel, Renate;Sinning, Christoph;Lackner, Karl J.;Tiret, Laurence;Nicaud, Viviane;Cambien, Francois;Bickel, Christoph;Rupprecht, Hans J.;Perret, Claire;Proust, Carole;Münzel, Thomas F.;Barbalic, Maja;Chen, Ida Yii-Der;Demissie-Banjaw, Serkalem;Folsom, Aaron;Lumley, Thomas;Marciante, Kristin;Taylor, Kent D.;Volcik, Kelly;Gretarsdottir, Solveig;Gulcher, Jeffrey R.;Kong, Augustine;Stefansson, Kari;Thorgeirsson, Gudmundur;Andersen, Karl;Fischer, Marcus;Grosshennig, Anika;Linsel-Nitschke, Patrick;Stark, Klaus;Schreiber, Stefan;Aherrahrou, Zouhair;Bruse, Petra;Doering, Angela;Klopp, Norman;Diemert, Patrick;Loley, Christina;Medack, Anja;Nahrstedt, Janja;Peters, Annette;Wagner, Arnika K.;Willenborg, Christina;Böhm, Bernhard O.;Dobnig, Harald;Grammer, Tanja B.;Hoffmann, Michael M.;Meinitzer, Andreas;Winkelmann, Bernhard R.;Pilz, Stefan;Renner, Wilfried;Scharnagl, Hubert;Stojakovic, Tatjana;Tomaschitz, Andreas;Winkler, Karl;Guiducci, Candace;Burtt, Noel;Gabriel, Stacey B.;Dandona, Sonny;Jarinova, Olga;Qu, Liming;Wilensky, Robert;Matthai, William;Hakonarson, Hakon H.;Devaney, Joe;Burnett, Mary Susan;Pichard, Augusto D.;Kent, Kenneth M.;Satler, Lowell;Lindsay, Joseph M.;Waksman, Ron;Knouff, Christopher W.;Waterworth, Dawn M.;Walker, Max C.;Epstein, Stephen E.;Rader, Daniel J.;Nelson, Christopher P.;Wright, Benjamin J.;Balmforth, Anthony J.;Ball, Stephen G.;Loehr, Laura R.;Rosamond, Wayne D.;Benjamin, Emelia;Haritunians, Talin;Couper, David;Murabito, Joanne;Wang, Ying A.;Stricker, Bruno H.;Chang, Patricia P.;Willerson, James T.;Felix, Stephan B.;Watzinger, Norbert;Aragam, Jayashri;Zweiker, Robert;Lind, Lars;Rodeheffer, Richard J.;Greiser, Karin Halina;Deckers, Jaap W.;Stritzke, Jan;Ingelsson, Erik;Kullo, Iftikhar;Haerting, Johannes;Reffelmann, Thorsten;Redfield, Margaret M.;Werdan, Karl;Mitchell, Gary F.;Arnett, Donna K.;Gottdiener, John S.;Blettner, Maria;Friedrich, Nele;Kovacs, Peter;Wild, Philipp S.;Froguel, Philippe;Rettig, Rainer;Mägi, Reedik;Biffar, Reiner;Schmidt, Reinhold;Middelberg, Rita P. S.;Carroll, Robert J.;Penninx, Brenda W.;Scott, Rodney J.;Katz, Ronit;Sedaghat, Sanaz;Wild, Sarah H.;Kardia, Sharon L. R.;Ulivi, Sheila;Hwang, Shih-Jen;Enroth, Stefan;Kloiber, Stefan;Trompet, Stella;Stengel, Benedicte;Hancock, Stephen J.;Turner, Stephen T.;Rosas, Sylvia E.;Stracke, Sylvia;Harris, Tamara B.;Zeller, Tanja;Zemunik, Tatijana;Lehtimäki, Terho;Illig, Thomas;Aspelund, Thor;Nikopensius, Tiit;Esko, Tonu;Tanaka, Toshiko;Gyllensten, Ulf;Völker, Uwe;Emilsson, Valur;Vitart, Veronique;Aalto, Ville;Gudnason, Vilmundur;Chouraki, Vincent;Chen, Wei-Min;Igl, Wilmar;März, Winfried;Koenig, Wolfgang;Lieb, Wolfgang;Loos, Ruth J. F.;Liu, Yongmei;Snieder, Harold;Pramstaller, Peter P.;Parsa, Afshin;O'Connell, Jeffrey R.;Susztak, Katalin;Hamet, Pavel;Tremblay, Johanne;De Boer, Ian H.;Böger, Carsten A.;Goessling, Wolfram;Chasman, Daniel I.;Köttgen, Anna;Kao, W. H. Linda;Fox, Caroline S.
2016-01-01
Abstract
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
2016
Gene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency; Chronic; Genetic Predisposition to Disease; Chemistry (all); Biochemistry; Genetics and Molecular Biology (all); Physics and Astronomy (all)
Files in This Item:
File | Size | Format | |
---|---|---|---|
Pattaro Nature CKD.pdf open access
Type: versione editoriale
Size 1.16 MB
Format Adobe PDF
|
1.16 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.